Non-coding RNAs with essential roles in neurodegenerative disorders

被引：218
作者：
Salta, Evgenia [1 ,2 ,3 ]
De Strooper, Bart [1 ,2 ,3 ]
机构：
[1] VIB Ctr Biol Dis VIB11, B-3000 Louvain, Belgium
[2] Univ Leuven, Ctr Human Genet, Louvain, Belgium
[3] Univ Leuven, Leuven Inst Neurodegenerat Disorders LIND, Louvain, Belgium
来源：
LANCET NEUROLOGY | 2012年 / 11卷 / 02期
基金：
欧洲研究理事会;
关键词：
NATURAL ANTISENSE TRANSCRIPTS; CENTRAL-NERVOUS-SYSTEM; MICRORNA TARGET SITES; TERM-MEMORY FORMATION; ALZHEIMERS-DISEASE; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE; GENE-EXPRESSION; BINDING-SITE; PERVASIVE TRANSCRIPTION;
D O I：
10.1016/S1474-4422(11)70286-1
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The importance of various classes of regulatory non-protein-coding RNA molecules (ncRNAs) in the normal functioning of the CNS is becoming increasingly evident. ncRNAs are involved in neuronal cell specification and patterning during development, but also in higher cognitive processes, such as structural plasticity and memory formation in the adult brain. We discuss advances in understanding of the function of ncRNAs in the CNS, with a focus on the potential involvement of specific species, such as microRNAs, endogenous small interfering RNAs, long intergenic non-coding RNAs, and natural antisense transcripts, in various neurodegenerative disorders. This emerging field is anticipated to profoundly affect clinical research, diagnosis, and therapy in neurology.
引用
收藏
页码：189 / 200
页数：12
相关论文
共 166 条
[61]   Widespread transcription at neuronal activity-regulated enhancers [J].
Kim, Tae-Kyung ;
Hemberg, Martin ;
Gray, Jesse M. ;
Costa, Allen M. ;
Bear, Daniel M. ;
Wu, Jing ;
Harmin, David A. ;
Laptewicz, Mike ;
Barbara-Haley, Kellie ;
Kuersten, Scott ;
Markenscoff-Papadimitriou, Eirene ;
Kuhl, Dietmar ;
Bito, Haruhiko ;
Worley, Paul F. ;
Kreiman, Gabriel ;
Greenberg, Michael E. .
NATURE, 2010, 465 (7295) :182-U65
[62]   MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction [J].
Kocerha, Jannet ;
Faghihi, Mohammad Ali ;
Lopez-Toledano, Miguel A. ;
Huang, Jia ;
Ramsey, Amy J. ;
Caron, Marc G. ;
Sales, Nicole ;
Willoughby, David ;
Elmen, Joacim ;
Hansen, Henrik F. ;
Orum, Henrik ;
Kauppinen, Sakari ;
Kenny, Paul J. ;
Wahlestedt, Claes .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (09) :3507-3512
[63]   A novel type of non-coding RNA expressed in the rat brain [J].
Komine, Y ;
Tanaka, NK ;
Yano, R ;
Takai, S ;
Yuasa, S ;
Shiroishi, T ;
Tsuchiya, K ;
Yamamori, T .
MOLECULAR BRAIN RESEARCH, 1999, 66 (1-2) :1-13
[64]   An untranslated CTG expansion causes a novel form of spinocerebellar ataxia (SCA8) [J].
Koob, MD ;
Moseley, ML ;
Schut, LJ ;
Benzow, KA ;
Bird, TD ;
Day, JW ;
Ranum, LPW .
NATURE GENETICS, 1999, 21 (04) :379-384
[65]  
Korneev S, 2005, REV NEUROSCIENCE, V16, P213
[66]   Timed and targeted differential regulation of nitric oxide synthase (NOS) and anti-NOS genes by reward conditioning leading to long-term memory formation [J].
Korneev, SA ;
Straub, V ;
Kemenes, I ;
Korneeva, EI ;
Ott, SR ;
Benjamin, PR ;
O'Shea, M .
JOURNAL OF NEUROSCIENCE, 2005, 25 (05) :1188-1192
[67]   Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis [J].
Kosaka, Nobuyoshi ;
Iguchi, Haruhisa ;
Ochiya, Takahiro .
CANCER SCIENCE, 2010, 101 (10) :2087-2092
[68]   The widespread regulation of microRNA biogenesis, function and decay [J].
Krol, Jacek ;
Loedige, Inga ;
Filipowicz, Witold .
NATURE REVIEWS GENETICS, 2010, 11 (09) :597-610
[69]   Transvascular delivery of small interfering RNA to the central nervous system [J].
Kumar, Priti ;
Wu, Haoquan ;
McBride, Jodi L. ;
Jung, Kyeong-Eun ;
Kim, Moon Hee ;
Davidson, Beverly L. ;
Lee, Sang Kyung ;
Shankar, Premlata ;
Manjunath, N. .
NATURE, 2007, 448 (7149) :39-43
[70]   A small modulatory dsRNA specifies the fate of adult neural stem cells [J].
Kuwabara, T ;
Hsieh, J ;
Nakashima, K ;
Taira, K ;
Gage, FH .
CELL, 2004, 116 (06) :779-793
234567891011