Urothelial malignant disease and Chinese herbal nephropathy

被引：157

作者：

Lord, GM ^{[1
]}

Cook, T

Arlt, VM

Schmeiser, HH

Williams, G

Pusey, CD

机构：

[1] Hammersmith Hosp NHS Trust, Div Renal Med & Transplantat, London W12 0NN, England

[2] Inst Canc Res, Haddow Labs, Surrey, England

[3] German Canc Res Ctr, Div Mol Toxicol, D-69120 Heidelberg, Germany

来源：

LANCET | 2001年 / 358卷 / 9292期

关键词：

D O I：

10.1016/S0140-6736(01)06576-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have previously reported occurrence of a specific type of nephropathy due to ingestion of Chinese herbs (Chinese herbal nephropathy [CHN]) In two patients In the UK. These cases highlighted the role of aristolochic acid In causing this nephropathy, which was first described In a Belgian cohort. We now report development of invasive transitional cell carcinoma of the! urinary tract associated with the presence of aristolochic acid-DNA adducts In one of these patients. This work clearly shows the carcinogenic potential of aristolochic acid In this new type of nephropathy.

引用

页码：1515 / 1516

页数：2

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