No evidence for association between the interferon regulatory factor 1 (IRF1) gene and clinical tuberculosis

被引：5

作者：

Vollstedt, Sabine ^{[1
,2
,3
]}

Yuliwulandari, Rika ^{[1
,4
]}

Okamoto, Koji ^{[5
]}

Lien, Luu Thi ^{[6
]}

Keicho, Naoto ^{[7
]}

Rochani, Jecti Teguh ^{[4
]}

Wikaningrum, Riyani ^{[4
]}

Tokunaga, Katsushi ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Human Genet, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Immunol, Tokyo 1130033, Japan

[3] Univ Tokyo, Fac Med, Tokyo 1130033, Japan

[4] Yarsi Univ, Fac Med, Jakarta, Indonesia

[5] Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Tokyo 1130033, Japan

[6] Hanoi TB & Lung Dis Hosp, Hanoi, Vietnam

[7] Int Med Ctr Japan, Inst Res, Dept Resp Dis, Tokyo, Japan

来源：

TUBERCULOSIS | 2009年 / 89卷 / 01期

关键词：

Tuberculosis; Interferon regulatory factor I (IRF1); SYSTEMIC-LUPUS-ERYTHEMATOSUS; TRANSCRIPTION FACTOR IRF-1; GAMMA RECEPTOR-1 GENE; TOLL-LIKE RECEPTORS; MYCOBACTERIUM-TUBERCULOSIS; FACTOR-I; PULMONARY TUBERCULOSIS; IMMUNE-RESPONSE; HOST-DEFENSE; SUSCEPTIBILITY;

D O I：

10.1016/j.tube.2008.09.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

interferon regulatory factor I is a transcription factor involved in initiating a Vigorous Th1 response during Mycobacterium tuberculosis infection. Therefore, we considered it as a possible candidate gene for certain polymorphisms to confer susceptibility to develop clinical tuberculosis. However, all polymorphisms with minor allele frequencies higher than 51, and haplotype frequencies in two Southeast Asian populations (Indonesian and Vietnamese) turned Out not to be associated with pulmonary tuberculosis. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：71 / 76

页数：6

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