Unraveling the Complexities of SIRT1-Mediated Mitochondrial Regulation in Skeletal Muscle

被引：31

作者：

Philp, Andrew ^{[1
]}

Schenk, Simon ^{[2
]}

机构：

[1] Univ Birmingham, Sch Sport & Exercise Sci, Birmingham, W Midlands, England

[2] Univ Calif San Diego, Dept Orthopaed Surg, La Jolla, CA 92093 USA

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2013年 / 41卷 / 03期

基金：

美国国家卫生研究院;

关键词：

exercise; sirtuins; acetylation; transcription; adaptation; TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA; CALORIC RESTRICTION; ENERGY-EXPENDITURE; SIRTUIN; DEACETYLASE; METABOLISM; MICE; BIOGENESIS; AMPK; ACTIVATION;

D O I：

10.1097/JES.0b013e3182956803

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Sirtuin 1 (SIRT1) is a purported central regulator of skeletal muscle mitochondrial biogenesis. Herein, we discuss our recent work using conditional mouse models, which highlight the complexities of SIRT1 biology in vivo, and question the role of SIRT1 in regulating mitochondrial function and mitochondrial adaptations to endurance exercise. Furthermore, we discuss the possible contribution of proposed SIRT1 substrates to muscle mitochondrial biogenesis.

引用

页码：174 / 181

页数：8

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