Dynamic Contrast-Enhanced and Diffusion-Weighted Magnetic Resonance Imaging Noninvasive Evaluation of Vascular Disrupting Treatment on Rabbit Liver Tumors

被引:14
作者
Shao, Haibo [1 ]
Ni, Yicheng [2 ]
Zhang, Jian [3 ]
Chen, Feng [2 ]
Dai, Xu [1 ]
Fan, Guoguang [1 ]
Sun, Ziping [4 ]
Xu, Ke [1 ]
机构
[1] China Med Univ, Affiliated Hosp 1, Dept Radiol, Shenyang, Peoples R China
[2] Univ Louvain, Dept Med Diagnost Sci, Sect Radiol, Louvain, Belgium
[3] Jiangsu Prov Acad Tradit Chinese Med, Nanjing, Peoples R China
[4] Shandong Acad Med Sci, Radiat Med Inst, Jinan, Peoples R China
来源
PLOS ONE | 2013年 / 8卷 / 12期
基金
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词
COMBRETASTATIN A-4 PHOSPHATE; TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; PHASE IB TRIAL; CANCER-THERAPY; A4; PHOSPHATE; AGENT OXI4503; SOLID TUMORS; MRI; CA4P; COMBINATION;
D O I
10.1371/journal.pone.0082649
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Evaluation of vascular disrupting treatment (VDT) is generally based on tumor size and enhancement on conventional magnetic resonance imaging (MRI) which, unfortunately, may be limited in providing satisfactory information. The purpose of the study is to evaluate consecutive changes of 20 rabbit VX2 liver tumors after VDT by dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI) at a 3.0 T MR unit. Twenty four hours after intravenous injection of Combretastatin A-4-phosphate (CA4P) at 20 mg/kg, DCE-MRI derived Maximum Slope of Increase (MSI) and Positive Enhancement Integral (PEI) decreased sharply due to sudden shutting down of tumor feeding vessels. DWI derived Apparent Diffusion Coefficient (ADC) in tumor periphery decreased because of ischemic cell edema. On day 4, an increase of MSI was probably caused by the recovery of blood supply. A remarkable increase of ADC represented a large scale of necrosis among tumors. On day 8, the blood perfusion further decreased and the extent of necrosis further increased, reflected by lower MSI and PEI values and higher ADC value. On day 12, a second decrease of ADC was noticed because the re-growth of periphery tumor. The experimental data indicate that the therapeutic effects of VDT may be noninvasively monitored with DCE-MRI (reflecting tumor blood perfusion) and DWI (reflecting the changes of histology), which provide powerful measures for assessment of anticancer treatments.
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页数:7
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