Novel therapies for hepatitis C - one pill fits all?

被引：169
作者：
Manns, Michael P. [1 ]
von Hahn, Thomas [1 ,2 ]
机构：
[1] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany
[2] Hannover Med Sch, Inst Mol Biol, D-30625 Hannover, Germany
来源：
NATURE REVIEWS DRUG DISCOVERY | 2013年 / 12卷 / 08期
关键词：
TREATMENT-NAIVE PATIENTS; HCV-GENOTYPE; SUSTAINED VIROLOGICAL RESPONSE; DEPENDENT RNA-POLYMERASE; INTERFERON-ALPHA-2B PLUS RIBAVIRIN; REPLICATION COMPLEX INHIBITOR; PEGINTERFERON ALPHA-2A ALPHA; CHRONIC NON-A; PROTEASE INHIBITOR; CRYSTAL-STRUCTURE;
D O I：
10.1038/nrd4050
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Almost 25 years after the hepatitis C virus (HCV) was identified, and following intense research and development efforts, a large number of direct-acting antiviral drugs are now beginning to reach patient care. Accordingly, the way in which care is delivered is evolving at a breath-taking pace. Here, we review the current and upcoming treatment options for HCV, describe the key challenges facing clinicians and drug developers and discuss how the landscape in the HCV arena will change over the coming years.
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收藏
页码：595 / 610
页数：16
相关论文
共 130 条
[1]   Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus [J].
Ago, H ;
Adachi, T ;
Yoshida, A ;
Yamamoto, M ;
Habuka, N ;
Yatsunami, K ;
Miyano, M .
STRUCTURE, 1999, 7 (11) :1417-1426
[2]   DETECTION OF ANTIBODY TO HEPATITIS-C VIRUS IN PROSPECTIVELY FOLLOWED TRANSFUSION RECIPIENTS WITH ACUTE AND CHRONIC NON-A-HEPATITIS, NON-B-HEPATITIS [J].
ALTER, HJ ;
PURCELL, RH ;
SHIH, JW ;
MELPOLDER, JC ;
HOUGHTON, M ;
CHOO, QL ;
KUO, G .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) :1494-1500
[3]   Hepatitis c virus and host cell lipids An intimate connection [J].
Alvisi, Gualtiero ;
Madan, Vanesa ;
Bartenschlager, Ralf .
RNA BIOLOGY, 2011, 8 (02) :258-269
[4]   Boceprevir for Previously Treated Chronic HCV Genotype 1 Infection [J].
Bacon, Bruce R. ;
Gordon, Stuart C. ;
Lawitz, Eric ;
Marcellin, Patrick ;
Vierling, John M. ;
Zeuzem, Stefan ;
Poordad, Fred ;
Goodman, Zachary D. ;
Sings, Heather L. ;
Poordad, Fred ;
Goodman, Zachary D. ;
Sings, Heather L. ;
Boparai, Navdeep ;
Burroughs, Margaret ;
Brass, Clifford A. ;
Albrecht, Janice K. ;
Esteban, Rafael .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (13) :1207-1217
[5]  
Blight KJ, 1998, ANTIVIR THER, V3, P71
[6]   Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus [J].
Bressanelli, S ;
Tomei, L ;
Roussel, A ;
Incitti, I ;
Vitale, RL ;
Mathieu, M ;
De Francesco, R ;
Rey, FA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (23) :13034-13039
[7]   EFFICACY OF TELAPREVIR DOSED TWICE DAILY VERSUS EVERY 8 HOURS BY IL28B GENOTYPE: RESULTS FROM THE PHASE III OPTIMIZE STUDY [J].
Buti, M. ;
Agarwal, K. ;
Horsmans, Y. ;
Sievert, W. ;
Janczewska, E. ;
Zeuzem, S. ;
Nyberg, L. ;
Brown, R. S., Jr. ;
Hezode, C. ;
Rizzetto, M. ;
Parana, R. ;
De Meyer, S. ;
DeMasi, R. ;
Luo, D. ;
Witek, J. .
JOURNAL OF HEPATOLOGY, 2013, 58 :S326-S326
[8]   Cost-effectiveness of boceprevir or telaprevir for untreated patients with genotype 1 chronic hepatitis C [J].
Camma, Calogero ;
Petta, Salvatore ;
Enea, Marco ;
Bruno, Raffaele ;
Bronte, Fabrizio ;
Capursi, Vincenza ;
Cicchetti, Americo ;
Colombo, Giorgio L. ;
Di Marco, Vito ;
Gasbarrini, Antonio ;
Craxi, Antonio .
HEPATOLOGY, 2012, 56 (03) :850-860
[9]   Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders [J].
Chayama, Kazuaki ;
Takahashi, Shoichi ;
Toyota, Joji ;
Karino, Yoshiyasu ;
Ikeda, Kenji ;
Ishikawa, Hiroki ;
Watanabe, Hideaki ;
McPhee, Fiona ;
Hughes, Eric ;
Kumada, Hiromitsu .
HEPATOLOGY, 2012, 55 (03) :742-748
[10]   ISOLATION OF A CDNA CLONE DERIVED FROM A BLOOD-BORNE NON-A, NON-B VIRAL-HEPATITIS GENOME [J].
CHOO, QL ;
KUO, G ;
WEINER, AJ ;
OVERBY, LR ;
BRADLEY, DW ;
HOUGHTON, M .
SCIENCE, 1989, 244 (4902) :359-362
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