Novel Organ Perfusion and Preservation Strategies in Transplantation - Where Are We Going in the United Kingdom?

被引：30

作者：

O'Neill, Stephen ^{[1
,2
]}

Srinivasa, Sanket ^{[1
]}

Callaghan, Chris J. ^{[3
]}

Watson, Christopher J. E. ^{[4
]}

Dark, John H. ^{[5
,6
]}

Fisher, Andrew J. ^{[5
,6
]}

Wilson, Colin H. ^{[5
,6
]}

Friend, Peter J. ^{[7
]}

Johnson, Rachel ^{[8
]}

Forsythe, John L. ^{[8
]}

Ploeg, Rutger J. ^{[7
]}

Mirza, Darius F. ^{[9
,10
]}

Wigmore, Stephen J. ^{[1
,11
]}

Oniscu, Gabriel C. ^{[1
,11
]}

机构：

[1] Royal Infirm Edinburgh NHS Trust, Edinburgh Transplant Ctr, Dept Transplant Surg, Edinburgh, Midlothian, Scotland

[2] Belfast City Hosp, Dept Transplant Surg, Belfast, Antrim, North Ireland

[3] Guys & St Thomas Hosp NHS Trust, Dept Nephrol & Transplantat, London, England

[4] Univ Cambridge, Addenbrookes Hosp Cambridge, Natl Inst Hlth Res NIHR, Dept Surg,Cambridge Biomed Res Ctr, Cambridge, England

[5] Newcastle Univ, Newcastle Tyne Hosp NHS Trust, Inst Transplantat, Freeman Hosp, Newcastle Upon Tyne, Tyne & Wear, England

[6] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England

[7] Univ Oxford, Nuffield Dept Surg Sci, Oxford Transplant Ctr, Oxford, England

[8] Natl Hlth Serv Blood & Transplant, Clin Trials Unit, Bristol, Avon, England

[9] Queen Elizabeth Hosp, Liver Unit, Birmingham, W Midlands, England

[10] Birmingham Childrens Hosp, Birmingham, W Midlands, England

[11] Univ Edinburgh, Dept Clin Surg, Edinburgh, Midlothian, Scotland

来源：

TRANSPLANTATION | 2020年 / 104卷 / 09期

关键词：

VIVO LUNG PERFUSION; HYPOTHERMIC MACHINE PERFUSION; STATIC COLD-STORAGE; HEART-BEATING DONORS; NORMOTHERMIC REGIONAL PERFUSION; HUMAN LIVER-TRANSPLANTATION; PRIMARY GRAFT DYSFUNCTION; BRAIN-DEATH DONORS; CIRCULATORY DEATH; CARDIAC DEATH;

D O I：

10.1097/TP.0000000000003106

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review article focuses on current clinical outcomes with novel perfusion strategies in organ transplantation. Broadly, these approaches can be divided into in situ regional perfusion in the donor and ex situ machine perfusion of individual organs. In both settings, hypothermic and normothermic techniques are in clinical use. Evidence from full text articles, abstracts, and data presented at scientific meetings has been considered. Animal studies have been excluded. The review focuses on kidney, liver, pancreas, heart, and lungs. The level of evidence ranges from quasi-experimental work in human pancreas to multiple meta-analyses of Randomized Controlled Trials for hypothermic machine perfusion of kidneys. The data in this review were presented to experts in organ perfusion and preservation at the National Health Service Blood and Transplant Preservation and Perfusion Future Strategy Summit in London in October 2018. The outcomes of the meeting are discussed in the review after due consideration of the available evidence base.

引用

页码：1813 / 1824

页数：12

共 11 条

[1] Novel Organ Perfusion and Preservation Strategies in Controlled Donation After Circulatory Death in Pancreas and Kidney Transplantation
Branchereau, J.
Ogbemudia, A. E.
Le Bas-Bernardet, S.
Prudhomme, T.
Rigaud, J.
Karam, G.
Blancho, G.
Mesnard, B.
TRANSPLANTATION PROCEEDINGS, 2022, 54 (01) : 77 - 79
[2] Machine perfusion in solid organ transplantation: where is the benefit?
Bruns, Helge
Schemmer, Peter
LANGENBECKS ARCHIVES OF SURGERY, 2014, 399 (04) : 421 - 427
[3] Pediatric liver transplantation: where do we stand? Where we are going to?
Devictor, Denis
Tissieres, Pierre
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 2013, 7 (07) : 629 - 641
[4] Machine perfusion preservation highlights from the Congress of the European Society of Organ Transplantation 2023
Faria, Isabella
Vidgren, Mathias
Canizares, Stalin
Devos, Lene
Reichel, Katrin
Oniscu, Gabriel C.
Martins, Paulo N.
ARTIFICIAL ORGANS, 2024, 48 (06) : 686 - 691
[5] Novel therapeutic strategies for renal graft preservation and their potential impact on the future of clinical transplantation
Juriasingani, Smriti
Akbari, Masoud
Luke, Patrick
Sener, Alp
CURRENT OPINION IN ORGAN TRANSPLANTATION, 2019, 24 (04) : 385 - 390
[6] Application of Mesenchymal Stem Cells During Machine Perfusion: An Emerging Novel Strategy for Organ Preservation
Li, Jiale
Peng, Qinbao
Yang, Ronghua
Li, Kunsheng
Zhu, Peng
Zhu, Yufeng
Zhou, Pengyu
Szabo, Gabor
Zheng, Shaoyi
FRONTIERS IN IMMUNOLOGY, 2021, 12
[7] Normothermic perfusion of donor lungs for preservation and assessment with the Organ Care System Lung before bilateral transplantation: a pilot study of 12 patients
Warnecke, Gregor
Moradiellos, Javier
Tudorache, Igor
Kuehn, Christian
Avsar, Murat
Wiegmann, Bettina
Sommer, Wiebke
Ius, Fabio
Kunze, Claudia
Gottlieb, Jens
Varela, Andres
Haverich, Axel
LANCET, 2012, 380 (9856) : 1851 - 1858
[8] Normothermic mechanical ex vivo perfusion of donor lungs Use of the Organ Care System Lung in preservation for transplantation
Warnecke, Gregor
ZEITSCHRIFT FUR HERZ THORAX UND GEFASSCHIRURGIE, 2021, 35 (04): : 242 - 247
[9] Split-Liver Ex Situ Machine Perfusion: A Novel Technique for Studying Organ Preservation and Therapeutic Interventions
Huang, Viola
Karimian, Negin
Detelich, Danielle
Raigani, Siavash
Geerts, Sharon
Beijert, Irene
Fontan, Fermin M.
Aburawi, Mohamed M.
Ozer, Sinan
Banik, Peony
Lin, Florence
Karabacak, Murat
Hafiz, Ehab O. A.
Porte, Robert J.
Uygun, Korkut
Markmann, James F.
Yeh, Heidi
JOURNAL OF CLINICAL MEDICINE, 2020, 9 (01)
[10] Impact of Donor Hepatectomy Time During Organ Procurement in Donation After Circulatory Death Liver Transplantation: The United Kingdom Experience
Farid, Shahid G.
Attia, Magdy S.
Vijayanand, Dhakshina
Upasani, Vivek
Barlow, Adam D.
Willis, Sean
Hidalgo, Ernest
Ahmad, Niaz
TRANSPLANTATION, 2019, 103 (04) : E79 - E88

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