Photoredox-Coupled F-Nucleophilic Addition: Allylation of gem-Difluoroalkenes

被引：102

作者：

Liu, Haidong ^{[1
]}

Ge, Liang ^{[1
]}

Wang, Ding-Xing ^{[1
]}

Chen, Nan ^{[1
]}

Feng, Chao ^{[1
]}

机构：

[1] Nanjing Tech Univ, Sch Chem & Mol Engn, Inst Adv Synth, Nanjing 210009, Jiangsu, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 12期

基金：

中国国家自然科学基金;

关键词：

allylic compounds; fluorine; photochemistry; radicals; reaction mechanisms; C-H AMINATION; CROSS-COUPLINGS; TRIFLUOROMETHYLATION; LIGHT; BOND; ACTIVATION; GENERATION; CATALYSIS; FLUORINE; RADICALS;

D O I：

10.1002/anie.201814308

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel strategy for the expedient construction of CF3-embeded tertiary/quartentary carbon centers was developed by taking advantage of photoredox catalysis. Thanks to a key step of single-electron oxidation, electron-rich gem-difluoroalkenes, which otherwise are essentially reluctant towards F-nucleoplilic addition, now readily participate in this fluoroallylation reaction. Furthermore, this strategy provides an elegant example for the generation, as well as functionalization, of alpha-CF3 -substituted benzylic radical intermediates using cheap and readily available starting materials.

引用

页码：3918 / 3922

页数：5

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