Human myoblast differentiation:: Ca2+ channels are activated by K+ channels

被引：0
|
作者：
Bernheim, L [1 ]
Bader, CR
机构：
[1] Univ Geneva, Ctr Med, Dept Physiol, CH-1211 Geneva 4, Switzerland
[2] Univ Geneva, Hop Cantonal, Div Rech Clin Neuromusculaire, Dept Neurosci Clin & Dermatol, CH-1211 Geneva, Switzerland
来源：
NEWS IN PHYSIOLOGICAL SCIENCES | 2002年 / 17卷
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D O I：
暂无
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
In a paradigm of cellular differentiation, human myoblast fusion, we investigated how a Ca2+ influx, indispensable for fusion, is triggered. We show how newly expressed Kir2.1 K+ channels, via their hyperpolarizing effect on the membrane potential, generate a window Ca2+ current (mediated by alpha 1H T-type Ca2+ channels), which causes intracellular Ca2+ to rise.
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页码：22 / 26
页数：5
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