The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function

被引：100

作者：

Parker, Matthew O. ^{[1
]}

Brock, Alistair J. ^{[1
]}

Walton, Robert T. ^{[1
]}

Brennan, Caroline H. ^{[1
]}

机构：

[1] Queen Mary Univ London, Sch Biol & Chem Sci, London E1 4NS, England

来源：

FRONTIERS IN NEURAL CIRCUITS | 2013年 / 7卷

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

zebrafish; attention; impulsivity; behavioral flexibility; psychiatric disorder; neural circuits; REACTION-TIME-TASK; NICOTINIC ACETYLCHOLINE-RECEPTORS; SUSTAINED ATTENTION; CORTICAL ACETYLCHOLINE; NUCLEUS-ACCUMBENS; 6-HYDROXYDOPAMINE LESIONS; PREFRONTAL CORTEX; NEURONAL-ACTIVITY; IMPULSIVE ACTION; RODENT MODELS;

D O I：

10.3389/fncir.2013.00063

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Zebrafish have great potential to contribute to our understanding of behavioral genetics and thus to contribute to our understanding of the etiology of psychiatric disease. However, progress is dependent upon the rate at which behavioural assays addressing complex behavioral phenotypes are designed, reported and validated. Here we critically review existing behavioral assays with particular focus on the use of adult zebrafish to explore executive process and phenotypes associated with human psychiatric disease. We outline the case for using zebrafish as models to study impulse control and attention, discussing the validity of applying extant rodent assays to zebrafish and evidence for the conservation of relevant neural circuits.

引用

页数：13

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