The role of smooth muscle derived tissue factor in mediating thrombosis and arterial injury

被引：15
作者：
Taubman, Mark B.
Wang, Li
Miller, Christine
机构：
[1] Univ Rochester, Aab Cardiovasc Res Inst, Rochester, NY USA
[2] Univ Rochester, Dept Med, Rochester, NY USA
来源：
THROMBOSIS RESEARCH | 2008年 / 122卷
关键词：
tissue factor; smooth muscle cells; intimal hyperplasia; thrombosis;
D O I：
10.1016/S0049-3848(08)70025-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Tissue factor (TF) is a glycoprotein that initiates coagulation, regulates hemostasis and plays a critical role in arterial thrombosis. Vascular smooth muscle cells (SMC) are the major cellular component of the arterial wall. Under normal conditions, SMC express minimal Levels of TF; however TF is rapidly induced in SMC by growth factors and cytokines and is expressed in abundance in arterial SMC in response to injury and during atherogenesis. Recent studies have suggested that SMC-derived TF plays an important role in promoting arterial thrombosis. and in mediating intimal hyperplasia in response to arterial injury. This latter role may be related to non-procoagulant properties of TF. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：S78 / S81
页数：4
相关论文
共 27 条
[1]   Fibrin-rich and platelet-rich thrombus formation on neointima: Recombinant tissue factor pathway inhibitor prevents fibrin formation and neointimal development following repeated balloon injury of rabbit aorta [J].
Asada, Y ;
Hara, S ;
Tsuneyoshi, A ;
Hatakeyama, K ;
Kisanuki, A ;
Marutsuka, K ;
Sato, Y ;
Kamikubo, Y ;
Sumiyoshi, A .
THROMBOSIS AND HAEMOSTASIS, 1998, 80 (03) :506-511
[2]   Signaling of the tissue factor coagulation pathway in angiogenesis and cancer [J].
Belting, M ;
Ahamed, J ;
Ruf, W .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (08) :1545-1550
[3]   Active tissue factor in blood? [J].
Butenas, S ;
Mann, KG .
NATURE MEDICINE, 2004, 10 (11) :1155-1156
[4]   Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa [J].
Camerer, E ;
Huang, W ;
Coughlin, SR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (10) :5255-5260
[5]   Coagulation factors VIIa and Xa induce cell signaling leading to up-regulation of the egr-1 gene [J].
Camerer, E ;
Rottingen, JA ;
Gjernes, E ;
Larsen, K ;
Skartlien, AH ;
Iversen, JG ;
Prydz, H .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (45) :32225-32233
[6]   Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation [J].
Chou, J ;
Mackman, N ;
Merrill-Skoloff, G ;
Pedersen, B ;
Furie, BC ;
Furie, B .
BLOOD, 2004, 104 (10) :3190-3197
[7]   Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall [J].
Day, SM ;
Reeve, JL ;
Pedersen, B ;
Farris, DM ;
Myers, DD ;
Im, M ;
Wakefield, TW ;
Mackman, N ;
Fay, WP .
BLOOD, 2005, 105 (01) :192-198
[8]   Blood-borne tissue factor:: Another view of thrombosis [J].
Giesen, PLA ;
Rauch, U ;
Bohrmann, B ;
Kling, D ;
Roqué, M ;
Fallon, JT ;
Badimon, JJ ;
Himber, J ;
Riederer, MA ;
Nemerson, Y .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) :2311-2315
[9]  
Golino P, 1998, CIRC RES, V82, P39
[10]   ANTITHROMBOTIC EFFECT OF A MONOCLONAL-ANTIBODY AGAINST TISSUE FACTOR IN A RABBIT MODEL OF PLATELET-MEDIATED ARTERIAL THROMBOSIS [J].
JANG, IK ;
GOLD, HK ;
LEINBACH, RC ;
FALLON, JT ;
COLLEN, D ;
WILCOX, JN .
ARTERIOSCLEROSIS AND THROMBOSIS, 1992, 12 (08) :948-954
123