CARDIAC REGENERATION

被引：55

作者：

Choi, Wen-Yee ^{[1
]}

Poss, Kenneth D. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Cell Biol, Durham, NC 27710 USA

来源：

HEART DEVELOPMENT | 2012年 / 100卷

关键词：

ZEBRAFISH HEART REGENERATION; HEMATOPOIETIC STEM-CELLS; ADULT NEWT; PROGENITOR CELLS; DNA-SYNTHESIS; CARDIOMYOCYTES; MOUSE; PROLIFERATION; MYOCYTES; INJURY;

D O I：

10.1016/B978-0-12-387786-4.00010-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The heart is a pump that is comprised of cardiac myocytes and other cell types and whose proper function is critical to quality of life. The ability to trigger regeneration of heart muscle following injury eludes adult mammals, a deficiency of great clinical impact. Major research efforts are attempting to change this through advances in cell therapy or activating endogenous regenerative mechanisms that exist only early in life. In contrast with mammals, lower vertebrates like zebrafish demonstrate an impressive natural capacity for cardiac regeneration throughout life. This review will cover recent progress in the field of heart regeneration with a focus on endogenous regenerative capacity and its potential manipulation.

引用

页码：319 / +

页数：27

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