LIPOPROTEIN (A) AND ARTERIAL STIFFNESS IN PATIENTS WITH DIABETES MELLITUS

Background: Type 2 Diabetes Mellitus (T2DM) increases morbidity and mortality of cardiovascular disease including atherosclerotic complications. The pathogenesis of atherosclerosis in T2DM is primarily due to changes in lipid profiles and lipoproteins. High levels of lipoprotein (a)/Lp (a) are known to be a risk factor for atherosclerosis. However, the correlation between Lp (a) levels and arterial stiffness has not been widely known. Objectives: To determine the correlation between Lp (a) and arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) in patients with T2DM in Endocrine Metabolic and Diabetes Unit of RSUD Dr. Soetomo Teaching Surabaya. Methods: The cross-sectional observational analytical research was conducted on T2DM patients aged >= 45 in Endocrine Metabolic and Diabetes Unit of Dr. Soetomo Teaching Hospital from June 2015 to August 2015. T2DM was determined based on the American Diabetes Association (ADA) 2014 criteria. Lp (a) was measured using Latex agglutination testand arterial stiffness was measured by baPWV. Results: Among 39 T2DM patients, 25.6% had Lp (a) >= 30 mg/dL with mean of Lp (a) levels of 21.66 +/- 18.67 mg/dL and 94.9% of patients had the mean of baPWV of 16.61 +/- 2.57 cm/s. The correlation result of Lp (a) and baPWV showed p = 0.88 and r = 0.026. Conclusion: There was no correlation between Lp (a) and arterial stiffness (using baPWV measurement) in patients with T2DM.