A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence

被引：130

作者：

de Souza, Camila Ferreira ^{[1
,2
]}

Sabedot, Thais S. ^{[1
,2
]}

Malta, Tathiane M. ^{[1
,2
]}

Stetson, Lindsay ^{[3
]}

Morozova, Olena ^{[4
,5
]}

Sokolov, Artem ^{[6
]}

Laird, Peter W. ^{[7
]}

Wiznerowicz, Maciej ^{[8
,9
,10
]}

Iavarone, Antonio ^{[11
,12
]}

Snyder, James ^{[1
]}

deCarvalho, Ana ^{[1
]}

Sanborn, Zachary ^{[13
]}

McDonald, Kerrie L. ^{[14
]}

Friedman, William A. ^{[15
]}

Tirapelli, Daniela ^{[16
]}

Poisson, Laila ^{[1
,17
]}

Mikkelsen, Tom ^{[1
]}

Carlotti, Carlos G., Jr. ^{[16
]}

Kalkanis, Steven ^{[1
]}

Zenklusen, Jean ^{[18
]}

Salama, Sofie R. ^{[4
,5
]}

Barnholtz-Sloan, Jill S. ^{[3
]}

Noushmehr, Houtan ^{[1
,2
]}

机构：

[1] Henry Ford Hlth Syst, Dept Neurosurg, Detroit, MI 48202 USA

[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Genet, Ribeirao Preto, SP, Brazil

[3] Case Western Reserve Univ, Sch Med, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA

[4] Univ Calif Santa Cruz, UC Santa Cruz Genom Inst, Santa Cruz, CA 95064 USA

[5] Univ Calif Santa Cruz, Howard Hughes Med Inst, Santa Cruz, CA 95064 USA

[6] Harvard Med Sch, Lab Syst Pharmacol, Boston, MA 02115 USA

[7] Van Andel Res Inst, Ctr Epigenet, Grand Rapids, MI 49503 USA

[8] Greater Poland Canc Ctr, Dept Diagnost & Canc Immunol, Lab Gene Therapy, Poznan, Poland

[9] Poznan Univ Med Sci, Dept Canc Immunol, Poznan, Poland

[10] Int Inst Mol Oncol, Poznan, Poland

[11] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA

[12] Columbia Univ, Neurol Inst Canc Genet, New York, NY 10032 USA

[13] NantOmics LLC, Santa Cruz, CA USA

[14] UNSW, Prince Wales Clin Sch, Cure Brain Canc Biomarkers & Translat Res Lab, Sydney, NSW, Australia

[15] Univ Florida, Dept Neurosurg, Gainesville, FL USA

[16] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Surg & Anat, Ribeirao Preto, Brazil

[17] Henry Ford Hlth Syst, Dept Publ Hlth Sci, Detroit, MI 48202 USA

[18] NCI, Bethesda, MD 20892 USA

来源：

CELL REPORTS | 2018年 / 23卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

INTEGRATED GENOMIC ANALYSIS; CENTRAL-NERVOUS-SYSTEM; STEM-CELLS; ADJUVANT TEMOZOLOMIDE; GLIOBLASTOMA; BRAIN; IDH1; REVEALS; MUTATIONS; RADIOTHERAPY;

D O I：

10.1016/j.celrep.2018.03.107

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Glioma diagnosis is based on histomorphology and grading; however, such classification does not have predictive clinical outcome after glioblastomas have developed. To date, no bona fide biomarkers that significantly translate into a survival benefit to glioblastoma patients have been identified. We previously reported that the IDH mutant G-CIMP-high subtype would be a predecessor to the G-CIMP-low subtype. Here, we performed a comprehensive DNA methylation longitudinal analysis of diffuse gliomas from 77 patients (200 tumors) to enlighten the epigenome-based malignant transformation of initially lower-grade gliomas. Intra-subtype heterogeneity among G-CIMP-high primary tumors allowed us to identify predictive biomarkers for assessing the risk of malignant recurrence at early stages of disease. G-CIMP-low recurrence appeared in 9.5% of all gliomas, and these resembled IDH-wild-type primary glioblastoma. G-CIMP-low recurrence can be characterized by distinct epigenetic changes at candidate functional tissue enhancers with AP-1/SOX binding elements, mesenchymal stem cell-like epigenomic phenotype, and genomic instability. Molecular abnormalities of longitudinal G-CIMP offer possibilities to defy glioblastoma progression.

引用

页码：637 / 651

页数：15

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