Vitamin D deficiency: infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder, autism, and schizophrenia)

被引:49
作者
Berridge, Michael J. [1 ]
机构
[1] Babraham Inst, Lab Mol Signalling, Cambridge CB22 3AT, England
来源
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2018年 / 314卷 / 02期
关键词
attention deficit hyperactivity disorder; autism; schizophrenia; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; ASSISTED REPRODUCTIVE TECHNOLOGY; MOUSE PREIMPLANTATION EMBRYOS; GATED CALCIUM-CHANNELS; SPERM PHOSPHOLIPASE-C; SPECTRUM DISORDERS; INTRACELLULAR CALCIUM; 25-HYDROXYVITAMIN D; BRAIN-DEVELOPMENT; BIPOLAR DISORDER;
D O I
10.1152/ajpcell.00188.2017
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The process of development depends on a number of signaling systems that regulates the progressive sequence of developmental events. Infertility and neurodevelopmental diseases, such as attention deficit hyperactivity disorder, autism spectrum disorders, and schizophrenia, are caused by specific alterations in these signaling processes. Calcium signaling plays a prominent role throughout development beginning at fertilization and continuing through early development, implantation, and organ differentiation such as heart and brain development. Vitamin D plays a major role in regulating these signaling processes that control development. There is an increase in infertility and an onset of neurodevelopmental diseases when vitamin D is deficient. The way in which vitamin D deficiency acts to alter development is a major feature of this review. One of the primary functions of vitamin D is to maintain the phenotypic stability of both the Ca2+ and redox signaling pathways that play such a key role throughout development.
引用
收藏
页码:C135 / C151
页数:17
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