Central nervous system involvement in anaplastic large cell lymphoma in childhood: Results from a multicentre European and Japanese study

被引：29

作者：

Williams, Denise ^{[1
]}

Mori, Tetsuya ^{[2
]}

Reiter, Alfred ^{[3
]}

Woessman, Wilhelm ^{[3
]}

Rosolen, Angelo ^{[4
]}

Wrobel, Grazyna ^{[5
]}

Zsiros, Jozsef ^{[6
]}

Uyttebroeck, Anne ^{[7
]}

Marky, Ildiko ^{[8
]}

Le Deley, Marie-Cecile ^{[9
,10
]}

Brugieres, Laurence ^{[11
]}

机构：

[1] Cambridge Univ Hosp NHS Trust, Dept Pediat Oncol, Cambridge CB2 0QQ, England

[2] Natl Ctr Child Hlth & Dev, Dept Paediat, Tokyo, Japan

[3] Univ Giessen, Nonhodgkin Lymphoma Berlin Frankfurt Muenster Stu, Dept Pediat Hematol & Oncol, D-35390 Giessen, Germany

[4] Univ Hosp, Dept Pediat, Padua, Italy

[5] Med Univ, Dept Bone Marrow Transplantat Children Oncol & He, Wroclaw, Poland

[6] Univ Amsterdam, Acad Med Ctr, Emma Kinderziekenhuis, Dept Paediat Oncol, NL-1105 AZ Amsterdam, Netherlands

[7] Univ Hosp, Dept Pediat Hematol Oncol, Louvain, Belgium

[8] Univ Gothenburg, Dept Pediat, Gothenburg, Sweden

[9] Inst Gustave Roussy, Biostat & Epidemiol Unit, Villejuif, France

[10] Univ Paris Sud, F-94275 Le Kremlin Bicetre, France

[11] Inst Gustave Roussy, Dept Pediat Oncol, Villejuif, France

来源：

PEDIATRIC BLOOD & CANCER | 2013年 / 60卷 / 10期

关键词：

anaplastic large cell lymphoma; childhood; CNS disease; lymphohistiocytic; non-Hodgkin lymphoma; NON-HODGKIN-LYMPHOMA; PEDIATRIC-ONCOLOGY; CHILDREN; ADOLESCENTS; TRIAL; CHEMOTHERAPY; VINBLASTINE; CRIZOTINIB;

D O I：

10.1002/pbc.24591

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In an international study of systemic childhood ALCL, 12/463 patients had CNS involvement, three of which had isolated CNS disease. Comparative analysis of CNS positive and negative patients showed no difference in ALK positivity, immunophenotype, presence of B symptoms or other sites of disease. The lymphohistiocytic variant was over represented in the CNS positive group (36% vs. 5%). With multi-agent chemotherapy, including high dose methotrexate, Ara-C and intrathecal treatment, the event free and overall survival of the CNS positive group at 5 years were 50% (95%CI, 25-75%) and 74% (45-91%), respectively with a median follow up of 4.1 years. Pediatr Blood Cancer 2013;60:E118-E121. (c) 2013 Wiley Periodicals, Inc.

引用

页码：E118 / E121

页数：4

共 20 条

[1] B and CTL responses to the ALK protein in patients with ALK-positive ALCL [J].

Ait-Taharl, K ;

Cerundolo, V ;

Banham, AH ;

Hatton, C ;

Blanchard, T ;

Kusec, R ;

Becker, M ;

Smith, GL ;

Pulford, K .

INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (03) :688-695

[2]

Brugières L, 1998, BLOOD, V92, P3591

[3] Single-Drug Vinblastine As Salvage Treatment for Refractory or Relapsed Anaplastic Large-Cell Lymphoma: A Report From the French Society of Pediatric Oncology [J].

Brugieres, Laurence ;

Pacquement, Helene ;

Le Deley, Marie-Cecile ;

Leverger, Guy ;

Lutz, Patrick ;

Paillard, Catherine ;

Baruchel, Andre ;

Frappaz, Didier ;

Nelken, Brigitte ;

Lamant, Laurence ;

Patte, Catherine .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (30) :5056-5061

[4] Impact of the Methotrexate Administration Dose on the Need for Intrathecal Treatment in Children and Adolescents With Anaplastic Large-Cell Lymphoma: Results of a Randomized Trial of the EICNHL Group [J].

Brugieres, Laurence ;

Le Deley, Marie-Cecile ;

Rosolen, Angelo ;

Williams, Denise ;

Horibe, Keizo ;

Wrobel, Grazyna ;

Mann, Georg ;

Zsiros, Jozsef ;

Uyttebroeck, Anne ;

Marky, Ildiko ;

Lamant, Laurence ;

Reiter, Alfred .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (06) :897-903

[5] Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents [J].

Cairo, Mitchell S. ;

Gerrard, Mary ;

Sposto, Richard ;

Auperin, Anne ;

Pinkerton, C. Ross ;

Michon, Jean ;

Weston, Claire ;

Perkins, Sherrie L. ;

Raphael, Martine ;

McCarthy, Keith ;

Patte, Catherine .

BLOOD, 2007, 109 (07) :2736-2743

[6] CSF Concentration of the Anaplastic Lymphoma Kinase Inhibitor Crizotinib [J].

Costa, Daniel B. ;

Kobayashi, Susumu ;

Pandya, Shuchi S. ;

Yeo, Wee-Lee ;

Shen, Zhongzhou ;

Tan, Weiwei ;

Wilner, Keith D. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15) :E443-E445

[7] Brentuximab Vedotin and Crizotinib in Anaplastic Large-Cell Lymphoma [J].

Foyil, Kelley V. ;

Bartlett, Nancy L. .

CANCER JOURNAL, 2012, 18 (05) :450-456

[8]

HARRIS NL, 1994, BLOOD, V84, P1361

[9] Primary cerebral ALK-1-Positive anaplastic large cell lymphoma in a child [J].

Karikari, Isaac O. ;

Thomas, Keyne K. ;

Lagoo, Anand ;

Cummings, Thomas J. ;

George, Timothy M. .

PEDIATRIC NEUROSURGERY, 2007, 43 (06) :516-521

[10] Prognostic Impact of Morphologic and Phenotypic Features of Childhood ALK-Positive Anaplastic Large-Cell Lymphoma: Results of the ALCL99 Study [J].

Lamant, Laurence ;

McCarthy, Keith ;

d'Amore, Emanuele ;

Klapper, Wolfram ;

Nakagawa, Atsuko ;

Fraga, Maximo ;

Maldyk, Jadwiga ;

Simonitsch-Klupp, Ingrid ;

Oschlies, Ilske ;

Delsol, Georges ;

Mauguen, Audrey ;

Brugieres, Laurence ;

Le Deley, Marie-Cecile .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (35) :4669-4676

← 1 2 →