Central nervous system involvement in anaplastic large cell lymphoma in childhood: Results from a multicentre European and Japanese study

被引：26

作者：

Williams, Denise ^{[1
]}

Mori, Tetsuya ^{[2
]}

Reiter, Alfred ^{[3
]}

Woessman, Wilhelm ^{[3
]}

Rosolen, Angelo ^{[4
]}

Wrobel, Grazyna ^{[5
]}

Zsiros, Jozsef ^{[6
]}

Uyttebroeck, Anne ^{[7
]}

Marky, Ildiko ^{[8
]}

Le Deley, Marie-Cecile ^{[9
,10
]}

Brugieres, Laurence ^{[11
]}

机构：

[1] Cambridge Univ Hosp NHS Trust, Dept Pediat Oncol, Cambridge CB2 0QQ, England

[2] Natl Ctr Child Hlth & Dev, Dept Paediat, Tokyo, Japan

[3] Univ Giessen, Nonhodgkin Lymphoma Berlin Frankfurt Muenster Stu, Dept Pediat Hematol & Oncol, D-35390 Giessen, Germany

[4] Univ Hosp, Dept Pediat, Padua, Italy

[5] Med Univ, Dept Bone Marrow Transplantat Children Oncol & He, Wroclaw, Poland

[6] Univ Amsterdam, Acad Med Ctr, Emma Kinderziekenhuis, Dept Paediat Oncol, NL-1105 AZ Amsterdam, Netherlands

[7] Univ Hosp, Dept Pediat Hematol Oncol, Louvain, Belgium

[8] Univ Gothenburg, Dept Pediat, Gothenburg, Sweden

[9] Inst Gustave Roussy, Biostat & Epidemiol Unit, Villejuif, France

[10] Univ Paris Sud, F-94275 Le Kremlin Bicetre, France

[11] Inst Gustave Roussy, Dept Pediat Oncol, Villejuif, France

来源：

PEDIATRIC BLOOD & CANCER | 2013年 / 60卷 / 10期

关键词：

anaplastic large cell lymphoma; childhood; CNS disease; lymphohistiocytic; non-Hodgkin lymphoma; NON-HODGKIN-LYMPHOMA; PEDIATRIC-ONCOLOGY; CHILDREN; ADOLESCENTS; TRIAL; CHEMOTHERAPY; VINBLASTINE; CRIZOTINIB;

D O I：

10.1002/pbc.24591

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In an international study of systemic childhood ALCL, 12/463 patients had CNS involvement, three of which had isolated CNS disease. Comparative analysis of CNS positive and negative patients showed no difference in ALK positivity, immunophenotype, presence of B symptoms or other sites of disease. The lymphohistiocytic variant was over represented in the CNS positive group (36% vs. 5%). With multi-agent chemotherapy, including high dose methotrexate, Ara-C and intrathecal treatment, the event free and overall survival of the CNS positive group at 5 years were 50% (95%CI, 25-75%) and 74% (45-91%), respectively with a median follow up of 4.1 years. Pediatr Blood Cancer 2013;60:E118-E121. (c) 2013 Wiley Periodicals, Inc.

引用

页码：E118 / E121

页数：4

共 20 条

[1] B and CTL responses to the ALK protein in patients with ALK-positive ALCL
Ait-Taharl, K
Cerundolo, V
Banham, AH
Hatton, C
Blanchard, T
Kusec, R
Becker, M
Smith, GL
Pulford, K
[J]. INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (03) : 688 - 695
[2] Brugières L, 1998, BLOOD, V92, P3591
[3] Single-Drug Vinblastine As Salvage Treatment for Refractory or Relapsed Anaplastic Large-Cell Lymphoma: A Report From the French Society of Pediatric Oncology
Brugieres, Laurence
Pacquement, Helene
Le Deley, Marie-Cecile
Leverger, Guy
Lutz, Patrick
Paillard, Catherine
Baruchel, Andre
Frappaz, Didier
Nelken, Brigitte
Lamant, Laurence
Patte, Catherine
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (30) : 5056 - 5061
[4] Impact of the Methotrexate Administration Dose on the Need for Intrathecal Treatment in Children and Adolescents With Anaplastic Large-Cell Lymphoma: Results of a Randomized Trial of the EICNHL Group
Brugieres, Laurence
Le Deley, Marie-Cecile
Rosolen, Angelo
Williams, Denise
Horibe, Keizo
Wrobel, Grazyna
Mann, Georg
Zsiros, Jozsef
Uyttebroeck, Anne
Marky, Ildiko
Lamant, Laurence
Reiter, Alfred
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (06) : 897 - 903
[5] Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents
Cairo, Mitchell S.
Gerrard, Mary
Sposto, Richard
Auperin, Anne
Pinkerton, C. Ross
Michon, Jean
Weston, Claire
Perkins, Sherrie L.
Raphael, Martine
McCarthy, Keith
Patte, Catherine
[J]. BLOOD, 2007, 109 (07) : 2736 - 2743
[6] CSF Concentration of the Anaplastic Lymphoma Kinase Inhibitor Crizotinib
Costa, Daniel B.
Kobayashi, Susumu
Pandya, Shuchi S.
Yeo, Wee-Lee
Shen, Zhongzhou
Tan, Weiwei
Wilner, Keith D.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15) : E443 - E445
[7] Brentuximab Vedotin and Crizotinib in Anaplastic Large-Cell Lymphoma
Foyil, Kelley V.
Bartlett, Nancy L.
[J]. CANCER JOURNAL, 2012, 18 (05) : 450 - 456
[8] HARRIS NL, 1994, BLOOD, V84, P1361
[9] Primary cerebral ALK-1-Positive anaplastic large cell lymphoma in a child
Karikari, Isaac O.
Thomas, Keyne K.
Lagoo, Anand
Cummings, Thomas J.
George, Timothy M.
[J]. PEDIATRIC NEUROSURGERY, 2007, 43 (06) : 516 - 521
[10] Prognostic Impact of Morphologic and Phenotypic Features of Childhood ALK-Positive Anaplastic Large-Cell Lymphoma: Results of the ALCL99 Study
Lamant, Laurence
McCarthy, Keith
d'Amore, Emanuele
Klapper, Wolfram
Nakagawa, Atsuko
Fraga, Maximo
Maldyk, Jadwiga
Simonitsch-Klupp, Ingrid
Oschlies, Ilske
Delsol, Georges
Mauguen, Audrey
Brugieres, Laurence
Le Deley, Marie-Cecile
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (35) : 4669 - 4676

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