The piRNA pathway in flies: highlights and future directions

被引：62

作者：

Guzzardo, Paloma M. ^{[1
]}

Muerdter, Felix ^{[1
]}

Hannon, Gregory J. ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2013年 / 23卷 / 01期

关键词：

PIWI-INTERACTING RNAS; NUAGE FORMATION; HISTONE H3; LYSINE; 9; DROSOPHILA; BIOGENESIS; PROTEIN; CHROMATIN; MECHANISM; ENCODES;

D O I：

10.1016/j.gde.2012.12.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Piwi proteins, together with their bound Piwi-interacting RNAs, constitute an evolutionarily conserved, germline-specific innate immune system. The piRNA pathway is one of the key mechanisms for silencing transposable elements in the germline, thereby preserving genome integrity between generations. Recent work from several groups has significantly advanced our understanding of how piRNAs arise from discrete genomic loci, termed piRNA clusters, and how these Piwi-piRNA complexes enforce transposon silencing. Here, we discuss these recent findings, as well as highlight some aspects of piRNA biology that continue to escape our understanding.

引用

页码：44 / 52

页数：9

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