Involvement of the nucleus accumbens and dopamine system in chronic pain

被引：44
作者：
Benarroch, Eduardo E. [1 ]
机构：
[1] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA
来源：
NEUROLOGY | 2016年 / 87卷 / 16期
关键词：
CHRONIC NEUROPATHIC PAIN; CHRONIC BACK-PAIN; AVERSIVE BEHAVIOR; BRAIN MECHANISMS; NOXIOUS STIMULI; BASAL GANGLIA; D2; RECEPTORS; REWARD; ANALGESIA; MODULATION;
D O I：
10.1212/WNL.0000000000003243
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Chronic pain syndrome is a complex disorder that includes not only the presence of spontaneous pain and exaggerated responses to painful and nonpainful stimuli but also the development of a negative affective, motivational, and cognitive state and the persistent desire to eliminate pain. Recent evidence indicates that chronic pain shares basic mechanisms with reward-based learning and drug addiction 1-3 and that the transition from acute to chronic pain reflects functional reorganization of this reward/motivational circuitry. 4 © 2016 American Academy of Neurology.
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收藏
页码：1720 / 1726
页数：7
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