Identification of TIM-3 as a Leukemic Stem Cell Surface Molecule in Primary Acute Myeloid Leukemia

被引：39

作者：

Kikushige, Yoshikane ^{[1
]}

Miyamoto, Toshihiro ^{[1
]}

机构：

[1] Kyushu Univ, Dept Med & Biosyst Sci, Grad Sch Med, Fukuoka 8128582, Japan

来源：

ONCOLOGY | 2015年 / 89卷

关键词：

Acute myeloid leukemia; Leukemic stem cell; T-cell immunoglobulin mucin-3; T-CELLS; APOPTOTIC CELLS; INFECTION; RECEPTOR; PHAGOCYTOSIS; GALECTIN-9; EXPRESSION; AUTOIMMUNE; TOLERANCE; HIERARCHY;

D O I：

10.1159/000431062

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute myeloid leukemia (AML) originates from self-renewing leukemic stem cells (LSCs), an ultimate therapeutic target in AML. Eradication of LSCs should be a critical and efficient-therapeutic approach for the cure of AML. T-cell immunoglobulin mucin-3 (TIM-3) is expressed in most types of AML LSCs, but not in normal hematopoietic stem cells (HSCs); therefore, TIM-3 would be one of the promising therapeutic targets to specifically kill AML LSCs, sparing normal HSCs. In xenograft models reconstituted with human AML LSCs or human normal HSCs, an anti-human TIM-3 mouse antibody with cytotoxic activities exerts a potent anti-leukemic effect by targeting AML LSCs but does not affect normal human hematopoiesis in vivo. Here, we would like to introduce the recent studies on TIM-3 in normal and malignant hematopoiesis. (C) 2015 S. Karger AG, Basel

引用

页码：28 / 32

页数：5

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