Evidence-based treatments of addiction

被引：86
作者：
O'Brien, Charles P. [1 ]
机构：
[1] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
来源：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2008年 / 363卷 / 1507期
关键词：
addiction; relapse; withdrawal; endophenotype;
D O I：
10.1098/rstb.2008.0105
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Both pharmacotherapy and behavioural treatment are required to relieve the symptoms of addictive disorders. This paper reviews the evidence for the benefits of pharmacotherapy and discusses mechanisms where possible. Animal models of addiction have led to some medications that are effective in reducing symptoms and improving function but they do not produce a cure. Addiction is a chronic disease that tends to recur when treatment is stopped; thus, long-term treatment is recommended.
引用
收藏
页码：3277 / 3286
页数：10
相关论文
共 75 条
  • [1] A comparison of the abuse liability of tramadol, NSAIDs, and hydrocodone in patients with chronic pain
    Adams, Edgar H.
    Breiner, Scott
    Cicero, Theodore J.
    Geller, Anne
    Inciardi, James A.
    Schnoll, Sidney H.
    Senay, Edward C.
    Woody, George E.
    [J]. JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 2006, 31 (05) : 465 - 476
  • [2] Ait-Daoud N, 2001, ALCOHOL CLIN EXP RES, V25, P847
  • [3] ALTERATION OF ETHANOL SELF-ADMINISTRATION BY NALTREXONE
    ALTSHULER, HL
    PHILLIPS, PE
    FEINHANDLER, DA
    [J]. LIFE SCIENCES, 1980, 26 (09) : 679 - 688
  • [4] Comparative Epidemiology of Dependence on Tobacco, Alcohol, Controlled Substances, and Inhalants: Basic Findings From the National Comorbidity Survey
    Anthony, James C.
    Warner, Lynn A.
    Kessler, Ronald C.
    [J]. EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 1994, 2 (03) : 244 - 268
  • [5] An evaluation of μ-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence
    Anton, Raymond F.
    Oroszi, Gabor
    O'Malley, Stephanie
    Couper, David
    Swift, Robert
    Pettinati, Helen
    Goldman, David
    [J]. ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (02) : 135 - 144
  • [6] Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity:: Possible implications for opiate addiction
    Bond, C
    LaForge, KS
    Tian, MT
    Melia, D
    Zhang, SW
    Borg, L
    Gong, JH
    Schluger, J
    Strong, JA
    Leal, SM
    Tischfield, JA
    Kreek, MJ
    Yu, L
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) : 9608 - 9613
  • [7] Safety and efficacy of γ-vinyl GABA (GVG) for the treatment of methamphetamine and/or cocaine addiction
    Brodie, JD
    Figueroa, E
    Laska, EM
    Dewey, SL
    [J]. SYNAPSE, 2005, 55 (02) : 122 - 125
  • [8] ALCOHOL DETOXIFICATION AND WITHDRAWAL SEIZURES - CLINICAL SUPPORT FOR A KINDLING HYPOTHESIS
    BROWN, ME
    ANTON, RF
    MALCOLM, R
    BALLENGER, JC
    [J]. BIOLOGICAL PSYCHIATRY, 1988, 23 (05) : 507 - 514
  • [9] Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients - A randomized placebo-controlled trial
    Carroll, KM
    Fenton, LR
    Ball, SA
    Nich, C
    Frankforter, TL
    Shi, J
    Rounsaville, BJ
    [J]. ARCHIVES OF GENERAL PSYCHIATRY, 2004, 61 (03) : 264 - 272
  • [10] Prelude to Passion: Limbic Activation by "Unseen" Drug and Sexual Cues
    Childress, Anna Rose
    Ehrman, Ronald N.
    Wang, Ze
    Li, Yin
    Sciortino, Nathan
    Hakun, Jonathan
    Jens, William
    Suh, Jesse
    Listerud, John
    Marquez, Kathleen
    Franklin, Teresa
    Langleben, Daniel
    Detre, John
    O'Brien, Charles P.
    [J]. PLOS ONE, 2008, 3 (01):
12345678