A virosomal vaccine against candidal vaginitis: Immunogenicity, efficacy and safety profile in animal models

被引：96

作者：

De Bernardis, Flavia ^{[1
]}

Amacker, Mario ^{[2
]}

Arancia, Silvia ^{[1
]}

Sandini, Silvia ^{[1
]}

Gremion, Christel ^{[2
]}

Zurbriggen, Rinaldo ^{[2
]}

Moser, Christian ^{[2
]}

Cassone, Antonio ^{[1
]}

机构：

[1] ISS, Dept Infect Parasit & Immunomediated Dis, Rome, Italy

[2] Pevion Biotech AG, CH-3032 Ittigen, Switzerland

来源：

VACCINE | 2012年 / 30卷 / 30期

关键词：

Candida albicans; Aspartyl proteinase 2; Virosomes; Vaccine; Recurrent vulvo-vaginal candidiasis; SECRETED ASPARTYL PROTEINASE; VULVO-VAGINAL CANDIDIASIS; DIFFERENTIAL EXPRESSION; IMMUNE-RESPONSES; FUNGAL DISEASES; GENE FAMILY; ALBICANS; VIRULENCE; PROTECTION; INFECTION;

D O I：

10.1016/j.vaccine.2012.04.069

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A novel vaccine (PEV7) consisting of a truncated, recombinant aspartyl proteinase-2 of Candida albicans incorporated into influenza virosomes was studied. This vaccine candidate generated a potent serum antibody response in mouse and rat following intramuscular immunization. Anti-Sap2 IgG and IgA were also detected in the vaginal fluid of rats following intravaginal or intramuscular plus intravaginal administration. In a rat model of candidal vaginitis, PEV7 induced significant, long-lasting, likely antibody-mediated, protection following intravaginal route of immunization. PEV7 was also found to be safe in a repeated-dose toxicological study in rats. Overall, these data provide a sound basis to envisage the clinical development of this new candidate vaccine against candidal vaginitis. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4490 / 4498

页数：9

共 40 条

[1] Frequency of interleukin-4 (IL-4)-589 gene polymorphism and vaginal concentrations of IL-4, nitric oxide, and mannose-binding lectin in women with recurrent vulvovaginal candidiasis [J].

Babula, O ;

Lazdane, G ;

Kroica, J ;

Linhares, IM ;

Ledger, WJ ;

Witkin, SS .

CLINICAL INFECTIOUS DISEASES, 2005, 40 (09) :1258-1262

[2] The secreted aspartic proteinases as a new target in the therapy of candidiasis [J].

Bein, M ;

Schaller, M ;

Korting, HC .

CURRENT DRUG TARGETS, 2002, 3 (05) :351-357

[3] Epaxal®: a virosomal vaccine to prevent hepatitis A infection [J].

Bovier, Patrick A. .

EXPERT REVIEW OF VACCINES, 2008, 7 (08) :1141-1150

[4] Strategies for mucosal vaccine development [J].

Boyaka, PN ;

Marinaro, M ;

Vancott, JL ;

Takahashi, I ;

Fujihashi, K ;

Yamamoto, M ;

van Ginkel, FW ;

Jackson, RJ ;

Kiyono, H ;

McGhee, JR .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1999, 60 (04) :35-45

[5] EVIDENCE FOR A CORRELATION BETWEEN PROTEINASE SECRETION AND VULVO-VAGINAL CANDIDOSIS [J].

CASSONE, A ;

DEBERNARDIS, F ;

MONDELLO, F ;

CEDDIA, T ;

AGATENSI, L .

JOURNAL OF INFECTIOUS DISEASES, 1987, 156 (05) :777-783

[6] RATS CLEARING A VAGINAL INFECTION BY CANDIDA-ALBICANS ACQUIRE SPECIFIC, ANTIBODY-MEDIATED RESISTANCE TO VAGINAL REINFECTION [J].

CASSONE, A ;

BOCCANERA, M ;

ADRIANI, D ;

SANTONI, G ;

DEBERNARDIS, F .

INFECTION AND IMMUNITY, 1995, 63 (07) :2619-2624

[7] Fungal vaccines: real progress from real challenges [J].

Cassone, Antonio .

LANCET INFECTIOUS DISEASES, 2008, 8 (02) :114-124

[8] Anticandidal immunity and vaginitis: Novel opportunities for immune intervention [J].

Cassone, Antonio ;

De Bernardis, Flavia ;

Santoni, Giorgio .

INFECTION AND IMMUNITY, 2007, 75 (10) :4675-4686

[9] Virosome-Formulated Plasmodium falciparum AMA-1 & CSP Derived Peptides as Malaria Vaccine: Randomized Phase 1b Trial in Semi-Immune Adults & Children [J].

Cech, Patrick Georges ;

Aebi, Thomas ;

Abdallah, Mwanajaa Shomari ;

Mpina, Maxmillian ;

Machunda, Ester Barnabas ;

Westerfeld, Nicole ;

Stoffel, Sabine Alexandra ;

Zurbriggen, Rinaldo ;

Pluschke, Gerd ;

Tanner, Marcel ;

Daubenberger, Claudia ;

Genton, Blaise ;

Abdulla, Salim .

PLOS ONE, 2011, 6 (07)

[10] Limited Role of Secreted Aspartyl Proteinases Sap1 to Sap6 in Candida albicans Virulence and Host Immune Response in Murine Hematogenously Disseminated Candidiasis [J].

Correia, Alexandra ;

Lermann, Ulrich ;

Teixeira, Luzia ;

Cerca, Filipe ;

Botelho, Sofia ;

Gil da Costa, Rui M. ;

Sampaio, Paula ;

Gaertner, Fatima ;

Morschhaeuser, Joachim ;

Vilanova, Manuel ;

Pais, Celia .

INFECTION AND IMMUNITY, 2010, 78 (11) :4839-4849

← 1 2 3 4 →