Rapid Resolution of Large Bowel Diarrhea after the Administration of a Combination of a High-Fiber Diet and a Probiotic Mixture in 30 Dogs

被引:17
作者
Rossi, Giacomo [1 ]
Cerquetella, Matteo [1 ]
Gavazza, Alessandra [1 ]
Galosi, Livio [1 ]
Berardi, Sara [1 ]
Mangiaterra, Sara [1 ]
Mari, Subeide [1 ]
Suchodolski, Jan S. [2 ]
Lidbury, Jonathan A. [2 ]
Steiner, Joerg M. [2 ]
Pengo, Graziano [3 ]
机构
[1] Univ Camerino, Sch Biosci & Vet Med, Via Circonvallaz 93-95, I-62024 Matelica, MC, Italy
[2] Texas A&M Univ, Dept Small Anim Clin Sci, Gastrointestinal Lab, College Stn, TX 77843 USA
[3] St Antonio Vet Clin, SS 415 Paullese 6, I-26020 Madignano, CR, Italy
关键词
colitis; food responsive diarrhea; gut homeostasis; high fiber; therapy; NECROSIS-FACTOR-ALPHA; LACTOBACILLUS-FERMENTUM; INFLAMMATION; MICROBIOTA; MODEL;
D O I
10.3390/vetsci7010021
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Canine fiber responsive diarrhea is a form of chronic colitis that improves clinically after adding fiber to the diet. In the present study, we investigated the effect of a combination of a high-fiber, highly digestible, hypoallergenic diet with a probiotic mixture in 30 dogs with chronic colitis that were unresponsive to various dietary and/or pharmacological interventions. Fecal scores, canine chronic enteropathy clinical activity index (CCECAI) scores, the dysbiosis index (DI), and histologic images of colonic biopsies were evaluated. At baseline (day 0; T0) and after 30 days of treatment (T1), all variables evaluated in our patients (i.e., fecal and CCECAI scores and histopathology) improved significantly at T1, with the exception of DI. However, there was a numerical shift from a state of dysbiosis to one of normobiosis. The combination of the diet and the probiotic used in the present study induced the resolution of clinical signs in a mean of 8.5 days (maximum 15 days) and did not necessitate any other treatments or the further addition of alimentary fiber.
引用
收藏
页数:10
相关论文
共 37 条
  • [1] Allenspach K, 2007, J VET INTERN MED, V21, P700, DOI 10.1892/0891-6640(2007)21[700:CEIDEO]2.0.CO
  • [2] 2
  • [3] A dysbiosis index to assess microbial changes in fecal samples of dogs with chronic inflammatory enteropathy
    AlShawaqfeh, M. K.
    Wajid, B.
    Minamoto, Y.
    Markel, M.
    Lidbury, J. A.
    Steiner, J. M.
    Serpedin, E.
    Suchodolski, J. S.
    [J]. FEMS MICROBIOLOGY ECOLOGY, 2017, 93 (11)
  • [4] SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model
    Bonfili, Laura
    Cecarini, Valentina
    Cuccioloni, Massimiliano
    Angeletti, Mauro
    Berardi, Sara
    Scarpona, Silvia
    Rossi, Giacomo
    Eleuteri, Anna Maria
    [J]. MOLECULAR NEUROBIOLOGY, 2018, 55 (10) : 7987 - 8000
  • [5] Increased mucosal tumour necrosis factor α production in Crohn's disease can be downregulated ex vivo by probiotic bacteria
    Borruel, N
    Carol, M
    Casellas, F
    Antolín, M
    de Lara, F
    Espín, E
    Naval, J
    Guarner, F
    Malagelada, JR
    [J]. GUT, 2002, 51 (05) : 659 - 664
  • [6] The intestinal anti-inflammatory effect of quercitrin is associated with an inhibition in iNOS expression
    Camuesco, D
    Comalada, M
    Rodriguez-Cabezas, ME
    Nieto, A
    Lorente, MD
    Concha, A
    Zarzuelo, A
    Gálvez, J
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2004, 143 (07) : 908 - 918
  • [7] Cerquetella Matteo, 2019, ScientificWorldJournal, V2019, P2742401, DOI 10.1155/2019/2742401
  • [8] Is irritable bowel syndrome also present in dogs?
    Cerquetella, Matteo
    Rossi, Giacomo
    Spaterna, Andrea
    Tesei, Beniamino
    Jergens, Albert E.
    Suchodolski, Jan S.
    Bassotti, Gabrio
    [J]. TIERAERZTLICHE PRAXIS AUSGABE KLEINTIERE HEIMTIERE, 2018, 46 (03): : 176 - 180
  • [9] Day MJ, 2008, J COMP PATHOL, V138, P1, DOI [10.1016/j.jcpa.2007.10.003, 10.1016/j.jcpa.2008.01.001]
  • [10] The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production
    Gálvez, J
    Garrido, M
    Rodrígues-Cabezas, ME
    Ramis, I
    de Medina, FS
    Merlos, M
    Zarzuelo, A
    [J]. INFLAMMATORY BOWEL DISEASES, 2003, 9 (06) : 363 - 371