Synthesis and Characterisation of 5-(6-substituted phenyl-2H-chromen-3-yl) Oxazole Derivatives

被引：3

作者：

Sadanandam, Palle ^{[1
]}

Sathaiah, Nomula ^{[2
]}

Jyothi, Vantikommu ^{[2
]}

Chari, Murugulla A. ^{[1
,2
,3
]}

Shobha, Donthabakthuni ^{[2
]}

Das, Parthasarathi ^{[4
]}

Mukkanti, Khagga ^{[1
]}

机构：

[1] Jawaharlal Nehru Technol Univ, Inst Sci & Technol, Dept Chem Sci, Hyderabad 85, Andhra Pradesh, India

[2] Dr MACS Biopharma Pvt Ltd, Hyderabad 500085, Andhra Pradesh, India

[3] Univ Tokyo, Dept Complex Sci & Engn, Sch Frontier Sci, Kashiwa, Chiba 2778561, Japan

[4] Aurigene Discovery Technol Ltd, Hyderabad 500049, Andhra Pradesh, India

来源：

LETTERS IN ORGANIC CHEMISTRY | 2012年 / 9卷 / 09期

关键词：

5-(substituted 2H-chromen-3-yl)-oxazoles; 5-(6-substituted phenyl-2H-chromen-3-yl)-oxazoles; suzuki coupling; TOSMIC reagent; CHROMAN DERIVATIVES; COMBINATORIAL LIBRARIES; PRIVILEGED STRUCTURES; 3-NITROCHROMENE DERIVATIVES; 1,3-DIPOLAR CYCLOADDITIONS; BIOLOGICAL-ACTIVITY; CONSTRUCTION; SALICYLALDEHYDES; 2H-CHROMENES; CYCLIZATION;

D O I：

10.2174/157017812803521126

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here we demonstrate the synthesis of various derivatives of 5-(6-substituted phenyl-2H-chromen-3-yl)-oxazoles 5(a-k) by using Suzuki coupling conditions with different substituted boronic acids and obtained 23-57 % yields. We also synthesised various derivatives of the 5-(substituted 2H-chromen-3-yl)-oxazoles 3(a-j) mediated by TOSMIC as a reagent and achieved 58-70 % yield.

引用

页码：683 / 690

页数：8

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