Hereditary multiple exostoses and solitary osteochondroma associated with growth hormone deficiency: to treat or not to treat?

被引:11
作者
Bozzola, Mauro [1 ]
Gertosio, Chiara [2 ]
Gnoli, Maria [3 ]
Baronio, Federico [4 ]
Pedrini, Elena [3 ]
Meazza, Cristina [1 ]
Sangiorgi, Luca [3 ]
机构
[1] Univ Pavia, Internal Med & Therapeut Dept, Pediat & Adolescent Unit, Fdn IRCCS Policlin San Matteo, I-27100 Pavia, Italy
[2] Univ Pavia, Fdn IRCCS Policlin San Matteo, I-27100 Pavia, Italy
[3] Univ Bologna, Pediat Endocrinol Program, Pediat Unit, S Orsola Malpighi Hosp, Bologna, Italy
[4] IOR, Med Genet Dept, Bologna, Italy
关键词
NATURAL-HISTORY; RISK; IDENTIFICATION; EXT1;
D O I
10.1186/s13052-015-0162-2
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background: Osteochondroma generally occurs as a single lesion and it is not a heritable disease. When two or more osteochondroma are present, this condition represents a genetic disorder named hereditary multiple exostoses (HME). Growth hormone deficiency (GHD) has rarely been found in HME patients and a few data about growth therapy (GH) therapy effects in development/growth of solitary or multiple exostoses have been reported. Case presentation: We describe the clinical features of 2 patients (one with osteochondroma and one with HME) evaluated before and after GH therapy. In the first patient, the single osteochondroma was noticed after the start of treatment; the other patient showed no evidence of significant increase in size or number of lesions related to GH therapy. Conclusion: It is necessary to investigate GH secretion in patients with osteochondroma or HME and short stature because they could benefit from GH replacement therapy. Moreover, careful clinical and imaging follow-up of exostoses is mandatory.
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页数:6
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