Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation

被引：93

作者：

Kumar, Deependra ^{[1
]}

Koyanagi, Iyo ^{[1
]}

Carrier-Ruiz, Alvaro ^{[2
,3
]}

Vergara, Pablo ^{[1
]}

Srinivasan, Sakthivel ^{[1
]}

Sugaya, Yuki ^{[2
,3
]}

Kasuya, Masatoshi ^{[1
]}

Yu, Tzong-Shiue ^{[4
]}

Vogt, Kaspar E. ^{[1
]}

Muratani, Masafumi ^{[5
]}

Ohnishi, Takaaki ^{[6
]}

Singh, Sima ^{[1
]}

Teixeira, Catia M. ^{[7
]}

Cherasse, Yoan ^{[1
]}

Naoi, Toshie ^{[1
]}

Wang, Szu-Han ^{[8
]}

Nondhalee, Pimpimon ^{[1
]}

Osman, Boran A. H. ^{[1
]}

Kaneko, Naoko ^{[9
]}

Sawamoto, Kazunobu ^{[9
,10
]}

Kernie, Steven G. ^{[4
]}

Sakurai, Takeshi ^{[1
]}

McHugh, Thomas J. ^{[11
]}

Kano, Masanobu ^{[2
,3
]}

Yanagisawa, Masashi ^{[1
]}

Sakaguchi, Masanori ^{[1
]}

机构：

[1] Univ Tsukuba, Int Inst Integrat Sleep Med WPI IIIS, Tsukuba, Ibaraki 3050006, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Neurophysiol, Tokyo 1130033, Japan

[3] Univ Tokyo, Int Res Ctr Neurointelligence WPI IRCN, Inst Adv Study UTIAS, Tokyo 1130033, Japan

[4] Columbia Univ Coll Phys & Surg, Dept Pediat, New York, NY 10032 USA

[5] Univ Tsukuba, Dept Genome Biol, Fac Med, Tsukuba, Ibaraki 3050006, Japan

[6] Univ Tokyo, Grad Sch Informat Sci & Technol, Tokyo 1138656, Japan

[7] Nathan S Kline Inst Psychiat Res, Emot Brain Inst, Orangeburg, NY 10962 USA

[8] Univ Edinburgh, Ctr Clin Brain Sci, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH16 4SB, Midlothian, Scotland

[9] Nagoya City Univ, Inst Brain Sci, Dept Dev & Regenerat Biol, Grad Sch Med Sci, Nagoya, Aichi 4678601, Japan

[10] Natl Inst Physiol Sci, Div Neural Dev & Regenerat, Okazaki, Aichi 4448585, Japan

[11] RIKEN Ctr Brain Sci, Wako, Saitama 3510106, Japan

来源：

NEURON | 2020年 / 107卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

SYNAPTIC PLASTICITY; GENE-EXPRESSION; GRANULE CELLS; THETA-RHYTHM; PROTEIN-SYNTHESIS; NEURAL ACTIVITY; CRITICAL PERIOD; STEM-CELLS; NEUROGENESIS; CALCIUM;

D O I：

10.1016/j.neuron.2020.05.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The occurrence of dreaming during rapid eye movement (REM) sleep prompts interest in the role of REM sleep in hippocampal-dependent episodic memory. Within the mammalian hippocampus, the dentate gyrus (DG) has the unique characteristic of exhibiting neurogenesis persisting into adulthood. Despite their small numbers and sparse activity, adult-born neurons (ABNs) in the DG play critical roles in memory; however, their memory function during sleep is unknown. Here, we investigate whether young ABN activity contributes to memory consolidation during sleep using Ca2+ imaging in freely moving mice. We found that contextual fear learning recruits a population of young ABNs that are reactivated during subsequent REM sleep against a backdrop of overall reduced ABN activity. Optogenetic silencing of this sparse ABN activity during REM sleep alters the structural remodeling of spines on ABN dendrites and impairs memory consolidation. These findings provide a causal link between ABN activity during REM sleep and memory consolidation.

引用

页码：552 / +

页数：24

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