Electroporation Enhances Bleomycin Efficacy in Cats with Periocular Carcinoma and Advanced Squamous Cell Carcinoma of the Head

被引：38
作者：
Spugnini, E. P. [1 ]
Pizzuto, M. [1 ,2 ]
Filipponi, M. [3 ]
Romani, L. [3 ]
Vincenzi, B. [4 ]
Menicagli, F. [2 ]
Lanza, A. [2 ]
De Girolamo, R. [2 ]
Lomonaco, R. [5 ]
Fanciulli, M. [1 ]
Spriano, G. [6 ]
Baldi, A. [7 ]
机构：
[1] Regina Elena Inst Canc Res, SAFU, Rome, Italy
[2] Ctr Vet Gianicolense, Rome, Italy
[3] Ctr Vet Casal Monastero, Rome, Italy
[4] Univ Campus Biomed, Med Oncol, Rome, Italy
[5] Ambulatorio Vet Dr Lomonaco, Rome, Italy
[6] Regina Elena Inst Canc Res, Dept Head & Neck Oncol, Rome, Italy
[7] Univ Naples 2, Dept Environm Biol & Pharmaceut Sci & Technol, Naples, Italy
来源：
JOURNAL OF VETERINARY INTERNAL MEDICINE | 2015年 / 29卷 / 05期
关键词：
Biphasic Pulses; Carcinoma; Electroporation; Feline; SENTINEL LYMPH-NODES; MALIGNANT MAMMARY-TUMORS; BREAST-CANCER; PROGNOSTIC-FACTORS; MICROMETASTASES; CONSENSUS; BIOPSY; DOGS; IDENTIFICATION; INVOLVEMENT;
D O I：
10.1111/jvim.13586
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Background: Advanced carcinoma of the head represents a substantial health problem in cats for local control and overall survival. Objectives: Evaluate the capability of electrochemotherapy ( ECT) to improve bleomycin efficacy in cats with periocular carcinoma and advanced carcinoma of the head. Animals: Twenty- one cats with periocular carcinoma ( 17 squamous cell carcinoma [ SCC] and 4 anaplastic carcinoma) and 26 cats with advanced SCC of the head. Methods: Nonrandomized prospective controlled study. Periocular carcinoma cohorts: 12 cats were treated with bleomycin ( 15 mg/ m 2 IV) coupled with ECT under anesthesia; 9 cats were treated with bleomycin alone. Advanced head SCC cohorts: 14 cats were treated with bleomycin ( 15 mg/ m 2 IV) coupled with ECT administered under sedation; 12 control cats were treated with bleomycin alone. ECT treatments ( 2- 8) were performed every other week until complete remission ( CR) or tumor progression occurred. Results: Toxicities were minimal and mostly treated symptomatically. Overall response rate in the ECT treated animals was 89% ( 21 Complete Response [ CR] and 2 Partial Response [ PR]) whereas controls had response rate of 33% ( 4 CR and 3 PR). Median time to progression in ECT group was 30.5 months, whereas in controls it was 3.9 months ( P <.0001). Median time to progression for ECT cohorts was 24.2 months for periocular cohort and 20.6 in advanced head SCC cohort, respectively. Conclusions: Electrochemotherapy is well tolerated for advanced SCC of the head in cats; its use may be considered among loco- regional strategies for cancer therapy in sensitive body regions such as periocular region.
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收藏
页码：1368 / 1375
页数：8
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