Electroporation Enhances Bleomycin Efficacy in Cats with Periocular Carcinoma and Advanced Squamous Cell Carcinoma of the Head

被引：38

作者：

Spugnini, E. P. ^{[1
]}

Pizzuto, M. ^{[1
,2
]}

Filipponi, M. ^{[3
]}

Romani, L. ^{[3
]}

Vincenzi, B. ^{[4
]}

Menicagli, F. ^{[2
]}

Lanza, A. ^{[2
]}

De Girolamo, R. ^{[2
]}

Lomonaco, R. ^{[5
]}

Fanciulli, M. ^{[1
]}

Spriano, G. ^{[6
]}

Baldi, A. ^{[7
]}

机构：

[1] Regina Elena Inst Canc Res, SAFU, Rome, Italy

[2] Ctr Vet Gianicolense, Rome, Italy

[3] Ctr Vet Casal Monastero, Rome, Italy

[4] Univ Campus Biomed, Med Oncol, Rome, Italy

[5] Ambulatorio Vet Dr Lomonaco, Rome, Italy

[6] Regina Elena Inst Canc Res, Dept Head & Neck Oncol, Rome, Italy

[7] Univ Naples 2, Dept Environm Biol & Pharmaceut Sci & Technol, Naples, Italy

来源：

JOURNAL OF VETERINARY INTERNAL MEDICINE | 2015年 / 29卷 / 05期

关键词：

Biphasic Pulses; Carcinoma; Electroporation; Feline; SENTINEL LYMPH-NODES; MALIGNANT MAMMARY-TUMORS; BREAST-CANCER; PROGNOSTIC-FACTORS; MICROMETASTASES; CONSENSUS; BIOPSY; DOGS; IDENTIFICATION; INVOLVEMENT;

D O I：

10.1111/jvim.13586

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Background: Advanced carcinoma of the head represents a substantial health problem in cats for local control and overall survival. Objectives: Evaluate the capability of electrochemotherapy ( ECT) to improve bleomycin efficacy in cats with periocular carcinoma and advanced carcinoma of the head. Animals: Twenty- one cats with periocular carcinoma ( 17 squamous cell carcinoma [ SCC] and 4 anaplastic carcinoma) and 26 cats with advanced SCC of the head. Methods: Nonrandomized prospective controlled study. Periocular carcinoma cohorts: 12 cats were treated with bleomycin ( 15 mg/ m 2 IV) coupled with ECT under anesthesia; 9 cats were treated with bleomycin alone. Advanced head SCC cohorts: 14 cats were treated with bleomycin ( 15 mg/ m 2 IV) coupled with ECT administered under sedation; 12 control cats were treated with bleomycin alone. ECT treatments ( 2- 8) were performed every other week until complete remission ( CR) or tumor progression occurred. Results: Toxicities were minimal and mostly treated symptomatically. Overall response rate in the ECT treated animals was 89% ( 21 Complete Response [ CR] and 2 Partial Response [ PR]) whereas controls had response rate of 33% ( 4 CR and 3 PR). Median time to progression in ECT group was 30.5 months, whereas in controls it was 3.9 months ( P <.0001). Median time to progression for ECT cohorts was 24.2 months for periocular cohort and 20.6 in advanced head SCC cohort, respectively. Conclusions: Electrochemotherapy is well tolerated for advanced SCC of the head in cats; its use may be considered among loco- regional strategies for cancer therapy in sensitive body regions such as periocular region.

引用

页码：1368 / 1375

页数：8

共 49 条

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