Prednisolone biotransformation by the green alga T76 Scenedesmus quadricauda

被引：5

作者：

DellaGreca, M

Previtera, L

Fiorentino, A

Pinto, G

Pollio, A

机构：

[1] UNIV NAPLES FEDERICO II,DIPARTIMENTO CHIM ORGAN & BIOL,I-80134 NAPLES,ITALY

[2] UNIV NAPLES 2,IST BIOL,I-81100 CASERTA,ITALY

[3] UNIV NAPLES FEDERICO II,DIPARTIMENTO BIOL VEGETALE,I-80139 NAPLES,ITALY

来源：

TETRAHEDRON | 1997年 / 53卷 / 24期

关键词：

D O I：

10.1016/S0040-4020(97)00493-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Exogenus prednisolone is biotransformed in cultures of the green alga T76 Scenedesmus quadricauda in two main bioproducts, which have been purified by chromatographic processes and identified by spectroscopic means. The first compound is the 5 alpha-hydroxyderivative of prednisolone and might be formed by a simple hydration of the Delta(4) double bond. The latter rises from a complex rearrangement. It is rather unstable and undergoes oxidation by atmospheric oxygen to a hydroperoxide which slowly decays to the corresponding hydroxyderivative. (C) 1997 Elsevier Science Ltd.

引用

页码：8273 / 8280

页数：8

共 8 条

[1] Rearrangements of exogenus 17 beta-hydroxy-17 alpha-methylandrosta-1,4-dien-3-one in cultures of the green alga T76 Scenedesmus quadricauda [J].