The effect of photobiomodulation on total amount of substance P in gingival crevicular fluid: placebo-controlled randomized clinical trial

被引:9
作者
Yildiz, Ezgi Doganay [1 ]
Arslan, Hakan [2 ]
Koseoglu, Serhat [3 ]
Arabaci, Taner [4 ]
Yildiz, Dursun Anil [4 ]
Savran, Levent [5 ]
机构
[1] Kirikkale Univ, Dept Endodont, Fac Dent, Kirikkale, Turkey
[2] Ataturk Univ, Dept Endodont, Fac Dent, Erzurum, Turkey
[3] Saglik Bilimleri Univ, Dept Periodontol, Fac Dent, Istanbul, Turkey
[4] Ataturk Univ, Dept Periodontol, Fac Dent, Erzurum, Turkey
[5] Izmir Katip Celebi Univ, Dept Periodontol, Fac Dent, Izmir, Turkey
关键词
Substance P; Photobiomodulation; Postoperative pain; Gingival crevicular fluid; LEVEL LASER THERAPY; GENE-RELATED PEPTIDE; SKIN; PAIN; NEUROPEPTIDES; IRRADIATION; MODULATION; MECHANISMS; EXTRACTION;
D O I
10.1007/s10103-018-2625-3
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
To investigate the effect of photobiomodulation (PBM) and placebo on total amount of substance P in gingival crevicular fluid (GCF) pre- and postoperatively. Twenty-six patients having tooth with symptomatic apical periodontitis were enrolled in this study. GCF was collected preoperatively. The patients were assigned into two groups (n=13), as follows: placebo and PBM. Sampling was repeated 7days after root canal treatment. Two independent samples T test was used for analyzing of the differences between preoperative and postoperative substance P levels in GCF (p=.05). The Pearson correlation analysis was used for determination of correlation among substance P levels and other variables. For placebo group, there is no significant difference between preoperative and postoperative total amounts of substance P level (p=0.553). For PBM group, postoperative total amount of substance P level was significantly higher than those of preoperative level (p=0.005). Within the limitation of the present study, PBM has immunomodulation effect linked to the modulation of the total amount of substance P in the gingival crevicular fluid. Thai Clinical Trials Registry: TCTR20161228002
引用
收藏
页码:517 / 523
页数:7
相关论文
共 39 条
[1]  
Abreu Marcelo Emir Requia, 2010, World J Orthod, V11, P273
[2]   On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide [J].
Antunes, F ;
Boveris, A ;
Cadenas, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (48) :16774-16779
[3]   The Effect of Low-Level Laser Therapy on Trismus and Facial Swelling Following Surgical Extraction of a Lower Third Molar [J].
Aras, Mutan Hamdi ;
Gungormus, Metin .
PHOTOMEDICINE AND LASER SURGERY, 2009, 27 (01) :21-24
[4]   Quantitative analysis of substance P, neurokinin A and calcitonin gene-related peptide in gingival crevicular fluid associated with painful human teeth [J].
Awawdeh, LA ;
Lundy, FT ;
Linden, GJ ;
Shaw, C ;
Kennedy, JG ;
Lamey, PJ .
EUROPEAN JOURNAL OF ORAL SCIENCES, 2002, 110 (03) :185-191
[5]   SUBSTANCE-P AND NITRIC-OXIDE MEDIATE WOUND-HEALING OF ULTRAVIOLET PHOTODAMAGED RAT SKIN - EVIDENCE FOR AN EFFECT OF NITRIC-OXIDE ON KERATINOCYTE PROLIFERATION [J].
BENRATH, J ;
ZIMMERMAN, M ;
GILLARDON, F .
NEUROSCIENCE LETTERS, 1995, 200 (01) :17-20
[6]   Low Level Laser Therapy in the Treatment of Intra-Osseous Defect-A Case Report [J].
Bhardwaj, Smiti ;
George, Joann Pauline ;
Remigus, Divakaran ;
Khanna, Divya .
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2016, 10 (03) :ZD6-ZD8
[7]   Exogenously administered substance P and neutral endopeptidase inhibitors stimulate fibroblast proliferation, angiogenesis and collagen organization during Achilles tendon healing [J].
Burssens, P ;
Steyaert, A ;
Forsyth, R ;
van Ovost, EJ ;
De Paepe, Y ;
Verdonk, R .
FOOT & ANKLE INTERNATIONAL, 2005, 26 (10) :832-839
[8]   The effect of single-file reciprocating systems on Substance P and Calcitonin gene-related peptide expression in human periodontal ligament [J].
Caviedes-Bucheli, J. ;
Moreno, J. O. ;
Carreno, C. P. ;
Delgado, R. ;
Garcia, D. J. ;
Solano, J. ;
Diaz, E. ;
Munoz, H. R. .
INTERNATIONAL ENDODONTIC JOURNAL, 2013, 46 (05) :419-426
[9]   Neuropeptides in dental pulp:: The silent protagonists [J].
Caviedes-Bucheli, Javier ;
Munoz, Hugo Roberto ;
Azuero-Holguin, Maria Mercedes ;
Ulate, Esteban .
JOURNAL OF ENDODONTICS, 2008, 34 (07) :773-788
[10]   CALIBRATION AND RELIABILITY OF THE PERIOTRON-6000 FOR INDIVIDUAL GINGIVAL CREVICULAR FLUID SAMPLES [J].
CHAPPLE, ILC ;
CROSS, IA ;
GLENWRIGHT, HD ;
MATTHEWS, JB .
JOURNAL OF PERIODONTAL RESEARCH, 1995, 30 (01) :73-79