Benefit and risk assessment of increasing potassium intake by replacement of sodium chloride with potassium chloride in industrial food products in Norway

被引:29
作者
Steffensen, Inger-Lise [1 ]
Frolich, Wenche [2 ]
Dahl, Knut Helkas [3 ]
Iversen, Per Ole [4 ,5 ]
Lyche, Jan Ludvig [6 ]
Lillegaard, Inger Therese Laugsand [7 ]
Alexander, Jan [8 ]
机构
[1] Norwegian Inst Publ Hlth, Dept Toxicol & Risk Assessment, POB 4404 Nydalen, NO-0403 Oslo, Norway
[2] Univ Stavanger, Norwegian Sch Hotel Management, POB 8600 Forus, N-4036 Stavanger, Norway
[3] Biosafe, Gronvoldvegen 675, NO-3830 Ulefoss, Norway
[4] Univ Oslo, Dept Nutr, POB 1046 Blindern, NO-0317 Oslo, Norway
[5] Oslo Univ Hosp, Dept Hematol, POB 4950 Nydalen, NO-0424 Oslo, Norway
[6] Norwegian Univ Life Sci, Dept Food Safety & Infect Biol, POB 8146 Dep, NO-0033 Oslo, Norway
[7] Norwegian Sci Comm Food Safety, POB 4404 Nydalen, NO-0403 Oslo, Norway
[8] Norwegian Inst Publ Hlth, Domain Infect Control & Environm Hlth, Off Director, POB 4404 Nydalen, NO-0403 Oslo, Norway
关键词
Benefit and risk assessment; Intake estimates; Potassium; Sodium; Vulnerable groups; BLOOD-PRESSURE; KCL SUPPLEMENTS; METAANALYSIS; HYPERTENSION; VALIDATION; REDUCTION; MAGNESIUM; RECALLS; STROKE; SALT;
D O I
10.1016/j.fct.2017.11.044
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
High sodium chloride (NaCl) intake is associated with health risks. NaCl may be replaced by potassium chloride (KCl) to decrease sodium intake. However, increased potassium may also have negative health effects. We conducted a benefit and risk assessment of increasing potassium by ratios of 30:70, 50:50, 70:30 (weight %K+: weight % Na+) in children, adolescents and adults in Norway, using intake data from national food consumption surveys and available literature on potassium health effects. An intake of at least 3.5 g/day of potassium decreases risk of stroke and hypertension, and this level was used in the benefit assessment of the healthy population. Three g/day of potassium added to mean food intake is assumed safe, and these levels were used in the risk assessment. Not all persons reached the protective level of potassium, and increasing numbers exceeded the safe levels, in these scenarios. In addition, elderly above 85 years and infants below one year of age, as well as several patient groups and medication users, are particularly vulnerable to hyperkalemia. In conclusion, the number of Norwegians facing increased risk is far greater than the number likely to benefit from this replacement of sodium with potassium in industrially produced food.
引用
收藏
页码:329 / 340
页数:12
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