The role of angiotensin-converting enzyme 2 in the pathogenesis of COVID-19: the villain or the hero?

被引：10

作者：

Klhufek, Josef ^{[1
]}

机构：

[1] T Bata Reg Hosp, Dept Pharm, Zlin 76275, Czech Republic

来源：

ACTA CLINICA BELGICA | 2022年 / 77卷 / 01期

关键词：

SARS-CoV-2; Covid-19; angiotensin-converting enzyme 2; smoking; elderly; diabetes; hypertension; ace-inhibitors; angiotensin receptors blockers; SARS-CORONAVIRUS; ACE2; EXPRESSION; FUNCTIONAL RECEPTOR; MESSENGER-RNA; RISK-FACTORS; POLYMORPHISM; SARS-COV-2; INHIBITORS; INSIGHTS; PROTEIN;

D O I：

10.1080/17843286.2020.1786324

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiotensin-converting enzyme 2 (ACE 2) is the entry receptor for the novel coronavirus SARS-CoV-2, the aetiological agent of COVID-19. At the same time, ACE 2 expression decreases during COVID-19. Two seemingly contradictory relationships between the expression of ACE 2 and COVID-19 have been reported. Increased level of expression of ACE 2 may be a risk factor for the development of COVID-19 infection, while reduced ACE 2 expression during COVID-19 leads to acute respiratory distress syndrome. This article provides a comprehensive overview of available scientific knowledge about the role of ACE 2 in the pathogenesis of COVID-19, which is available up to current day. Also, it discusses unknown factors that we will have to reveal in order to understand the whole role of ACE 2 in the pathogenesis of COVID-19.

引用

页码：211 / 218

页数：8

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