Near-Infrared Light-Responsive Intracellular Drug and siRNA Release Using Au Nanoensembles with Oligonucleotide-Capped Silica Shell

被引：177

作者：

Chang, Yi-Ting ^{[2
,3
]}

Liao, Pei-Yi ^{[2
,3
]}

Sheu, Hwo-Shuenn ^{[5
]}

Tseng, Yu-Jui ^{[4
]}

Cheng, Fong-Yu ^{[1
]}

Yeh, Chen-Sheng ^{[2
,3
]}

机构：

[1] Natl Cheng Kung Univ, Inst Oral Med, Tainan 701, Taiwan

[2] Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan

[3] Natl Cheng Kung Univ, Ctr Micro Nano Sci & Technol, Tainan 701, Taiwan

[4] Natl Cheng Kung Univ, Inst Nanotechnol & Microsyst Engn, Tainan 701, Taiwan

[5] Natl Synchrotron Radiat Res Ctr, Hsinchu 30076, Taiwan

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 25期

关键词：

drug delivery; Au nanorods; mesoporous silica; DNA; siRNA; MESOPOROUS SILICA; MECHANIZED NANOPARTICLES; GOLD NANORODS; NANOCONTAINERS; MOLECULES; DELIVERY; CELLS;

D O I：

10.1002/adma.201200785

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Taking advantage of the character of Au nanorods (NRs) to absorb NIR light, a NIR-responsive oligonucleotide-gated ensemble is developed to perform intracellular drug delivery. Using an oligonucleotide bio-gate enables siRNA release into cells for translational regulation as well as cytotoxicity in anti-cancer drug delivery. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3309 / 3314

页数：6

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