Neuroblastoma with orbital metastasis: ophthalmic presentation and role of ophthalmologists

被引:31
作者
Ahmed, S [1 ]
Goel, S [1 ]
Khandwala, M [1 ]
Agrawal, A [1 ]
Chang, B [1 ]
Simmons, IG [1 ]
机构
[1] Leeds Teaching Hosp NHS Trust, Dept Ophthalmol, Leeds LS9 7TF, W Yorkshire, England
关键词
orbital; neuroblastoma; ophthalmology; metastasis;
D O I
10.1038/sj.eye.6701912
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Introduction Neuroblastoma is predominantly a tumour of early childhood, which metastasises to the orbits. In such cases, ophthalmologists are involved in the multidisciplinary management. This unique series from a tertiary referral centre is used to elaborate the ophthalmic associations and the ophthalmologist's role in this rare condition. Methods A review of case notes was performed on six patients who presented to the paediatric ophthalmology - oncology liaison service at the Leeds teaching hospitals between 1998 and 2003. The ophthalmic outcome and role of the ophthalmologist were assessed. Results Average age of presentation was 29.8 months ( range 15 - 69 months). Average duration of follow-up was 19.5 months ( range 2 - 58 months). One child died during treatment. Two have completed treatment and are under follow-up. Presenting features of the six children were proptosis in four, periorbital ecchymosis in two, ocular motility restriction in two, and subconjunctival haemorrhage in one. Only one case developed blindness. Conclusions The role of the ophthalmologist in patients with metastatic orbital neuroblastoma can vary from a supportive role to one of active intervention and management of ophthalmic complications. The ophthalmologist is involved in diagnosis and staging as well as monitoring response to treatment of both the primary disease and secondary ophthalmic complications.
引用
收藏
页码:466 / 470
页数:5
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