Association of Adiponectin Gene Polymorphism (+T45G) With Acute Coronary Syndrome and Circulating Adiponectin Levels

被引：21
作者：
Rizk, Nasser M. [1 ]
El-Menyar, Ayman [2 ,3 ]
Marei, Isra [1 ]
Sameer, Maha [1 ]
Musad, Tasneem [1 ]
Younis, Dima [1 ]
Farag, Fathi [4 ]
Basem, Nora [5 ]
Al-Ali, Khalid [1 ]
Al Suwaidi, Jassim [2 ]
机构：
[1] Qatar Univ, Coll Arts & Sci, Doha, Qatar
[2] HMC, Heart Hosp, Dept Cardiol, Doha, Qatar
[3] Weill Cornell Med Sch, Doha, Qatar
[4] Al Emadi Hosp, Doha, Qatar
[5] Hamad Med Corp, Dept Clin Chem, Doha, Qatar
来源：
ANGIOLOGY | 2013年 / 64卷 / 04期
关键词：
adiponectin; polymorphism; gene; acute coronary syndrome; SINGLE-NUCLEOTIDE POLYMORPHISMS; MOLECULAR-WEIGHT ADIPONECTIN; ARTERY-DISEASE; APM1; GENE; INSULIN-RESISTANCE; SERUM ADIPONECTIN; DIABETES-MELLITUS; PLASMA-PROTEIN; RISK; LOCUS;
D O I：
10.1177/0003319712455497
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
We investigated the association of adiponectin gene polymorphisms (+T45G and +G276T) and adiponectin levels with acute coronary syndrome (ACS) among Arabs in Qatar. A case-control study was performed in 142 Arab patients with ACS and 122 controls. Genotypes were determined using TaqMan real-time polymerase chain reaction assay. The TT, TG, and GG genotype frequencies of the T45G variant were significantly different among cases and controls (P = .023) but not significant for G276T genotypic frequencies. It was found that only the +45G allele was significantly associated with 3-fold increased risk of ACS (odds ratio = 2.77; 1.03-6.96; P = .043) among patients, using the genetic recessive model. Carriers of GG alleles had significantly lower adiponectin levels compared to TT/TG carriers of T45G in patients with ACS. The present study suggests that only T45G single-nucleotide polymorphism in the adiponectin gene is associated with higher odds for ACS events and has an effect on serum adiponectin levels among Arab populations.
引用
收藏
页码：257 / 265
页数：9
相关论文
共 46 条
[1]   Adiponectin gene variants and the risk of coronary artery disease in patients with type 2 diabetes [J].
Al-Daghri, Nasser M. ;
Al-Attas, Omar S. ;
Alokail, Majed S. ;
Alkharfy, Khalid M. ;
Hussain, Tajamul .
MOLECULAR BIOLOGY REPORTS, 2011, 38 (06) :3703-3708
[2]   Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity [J].
Arita, Y ;
Kihara, S ;
Ouchi, N ;
Takahashi, M ;
Maeda, K ;
Miyagawa, J ;
Hotta, K ;
Shimomura, I ;
Nakamura, T ;
Miyaoka, K ;
Kuriyama, H ;
Nishida, M ;
Yamashita, S ;
Okubo, K ;
Matsubara, K ;
Muraguchi, M ;
Ohmoto, Y ;
Funahashi, T ;
Matsuzawa, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) :79-83
[3]   Should Adipokines be Considered in the Choice of the Treatment of Obesity-Related Health Problems? [J].
Athyros, Vasilios G. ;
Tziomalos, Konstantinos ;
Karagiannis, Asterios ;
Anagnostis, Panagiotis ;
Mikhailidis, Dimitri P. .
CURRENT DRUG TARGETS, 2010, 11 (01) :122-135
[4]   The +276G/T single nucleotide polymorphism of the adiponectin gene is associated with coronary artery disease in type 2 diabetic patients [J].
Bacci, S ;
Menzaghi, C ;
Ercolino, T ;
Ma, XW ;
Rauseo, A ;
Salvemini, L ;
Vigna, C ;
Fanelli, R ;
Di Mario, U ;
Doria, A ;
Trischitta, V .
DIABETES CARE, 2004, 27 (08) :2015-2020
[5]   Single-nucleotide polymorphisms at the adiponectin locus and risk of coronary artery disease in Tunisian coronaries [J].
Boumaiza, Imen ;
Omezzine, Asma ;
Rejeb, Jihene ;
Rebhi, Lamia ;
Ben Rejeb, Nabila ;
Nabli, Naoufel ;
Ben Abdelaziz, Ahmed ;
Boughzala, Essia ;
Bouslama, Ali .
JOURNAL OF CARDIOVASCULAR MEDICINE, 2011, 12 (09) :619-624
[6]   Listening to silence and understanding nonsense: Exonic mutations that affect splicing [J].
Cartegni, L ;
Chew, SL ;
Krainer, AR .
NATURE REVIEWS GENETICS, 2002, 3 (04) :285-298
[7]   The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome [J].
Comuzzie, AG ;
Funahashi, T ;
Sonnenberg, G ;
Martin, LJ ;
Jacob, HJ ;
Black, AEK ;
Maas, D ;
Takahashi, M ;
Kihara, S ;
Tanaka, S ;
Matsuzawa, Y ;
Blangero, J ;
Cohen, D ;
Kissebah, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (09) :4321-4325
[8]   The 3′ untranslated region of messenger RNA:: A molecular 'hotspot' for pathology? [J].
Conne, B ;
Stutz, A ;
Vassalli, JD .
NATURE MEDICINE, 2000, 6 (06) :637-641
[9]   Total and high molecular weight adiponectin in patients with coronary artery disease [J].
El-Menyar, Ayman ;
Rizk, Nasser ;
Al Nabti, Abdulrahman D. ;
Abu Hassira, Sana ;
Singh, Rajvir ;
Rahman, Mohamed Osman Abdel ;
Al Suwaidi, Jassim .
JOURNAL OF CARDIOVASCULAR MEDICINE, 2009, 10 (04) :310-315
[10]   Association of+45(T/G) and+276(G/T) polymorphisms in the adiponectin gene with coronary artery disease in a population of Iranian patients with type 2 diabetes [J].
Esteghamati, Alireza ;
Mansournia, Nasrin ;
Nakhjavani, Manouchehr ;
Mansournia, Mohammad Ali ;
Nikzamir, Abdolrahim ;
Abbasi, Mehrshad .
MOLECULAR BIOLOGY REPORTS, 2012, 39 (04) :3791-3797
12345