Synthesis, characterization and dynamic NMR studies of a novel chalcone based N-substituted morpholine derivative

被引：11
|
作者：
Baskar, R. [1 ]
Baby, C. [2 ]
Moni, M. S. [2 ]
Subramanian, K. [1 ]
机构：
[1] Anna Univ, Dept Chem, Madras 600025, Tamil Nadu, India
[2] Indian Inst Technol, Sophisticated Analyt Instrument Facil, Madras 600036, Tamil Nadu, India
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2013年 / 1040卷
关键词：
Morpholine; Dynamic NMR; Ring inversion; INVERSION; MOLECULES; POTENT; RING;
D O I：
10.1016/j.molstruc.2013.02.029
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The synthesis of a novel chalcone based N-substituted morpholine derivative namely, (E)-1-(biphenyl-4-yl)-3-(4-(5-morpholinopentyloxy) phenyl) prop-2-en-1-one (BMPP), using a two step protocol is reported. The compound is characterized by FTIR, GC-MS and FTNMR spectroscopy techniques. Advanced 2D NMR techniques such as gradient enhanced COSY, HSQC, HMBC and NOESY were employed to establish through-bond and through-space correlations. Dynamic NMR measurements were carried out to obtain the energy barrier to ring inversion of the morpholine moiety. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：90 / 97
页数：8
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