Polycyclic Hybrid Isoprenoids from a Reed Rhizosphere Soil Derived Streptomyces sp CHQ-64

被引：36

作者：

Che, Qian ^{[1
]}

Zhu, Tianjiao ^{[1
]}

Keyzers, Robert A. ^{[2
]}

Liu, Xiaofang ^{[1
]}

Li, Jing ^{[3
]}

Gu, Qianqun ^{[1
]}

Li, Dehai ^{[1
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[2] Victoria Univ Wellington, Sch Chem & Phys Sci, Wellington 6140, New Zealand

[3] Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 04期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

NATURAL-PRODUCTS; INDOLOSESQUITERPENE; ACTINOMYCETE; SUAVEOLENS;

D O I：

10.1021/np3008864

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new hybrid isoprenoids, named indotertine B (2) and drimentine H (3), along with the known analogue drimentine C (4), were isolated from the reed rhizosphere soil derived actinomycete Streptomyces sp. CHQ-64. The structures of these compounds, including absolute configurations, were elucidated by extensive NMR, MS, and CD analyses. Indotertine B (2) exists as a pair of rotamers about the N-C(O) bond with a 2:1 ratio and displays activities against HCT-8 and A549 tumor cell lines with IC50 values of 6.96 and 4.88 mu M, respectively.

引用

页码：759 / 763

页数：5

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