Inflammasomes in liver diseases

被引：470
作者：
Szabo, Gyongyi [1 ]
Csak, Timea [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA
来源：
JOURNAL OF HEPATOLOGY | 2012年 / 57卷 / 03期
关键词：
Inflammasomes; Interleukin-1; beta; Caspase-1; Drug induced liver injury; Ischaemiareperfusion; Endotoxin; Steatohepatitis; Viral hepatitis; Fibrosis; INTERLEUKIN-1 RECEPTOR ANTAGONIST; ACETAMINOPHEN-INDUCED HEPATOTOXICITY; HEPATIC ISCHEMIA/REPERFUSION INJURY; ISCHEMIA-REPERFUSION INJURY; CASPASE RECRUITMENT DOMAIN; III SECRETION APPARATUS; INNATE IMMUNE-RESPONSE; NECROSIS-FACTOR-ALPHA; ANTHRAX LETHAL TOXIN; VIRUS CORE PROTEIN;
D O I：
10.1016/j.jhep.2012.03.035
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Inflammation is a common element in the pathogenesis of most chronic liver diseases that lead to fibrosis and cirrhosis. Inflammation is characterized by activation of innate immune cells and production of pro-inflammatory cytokines IL-1 alpha, IL-1 beta, and TNF alpha. Inflammasomes are intracellular multiprotein complexes expressed in both parenchymal and non-parenchymal cells of the liver that in response to cellular danger signals activate caspase-1, and release IL-1 beta and IL-18. The importance of inflamma-some activation in various forms of liver diseases in relation to liver damage, steatosis, inflammation and fibrosis is discussed in this review. (C) 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：642 / 654
页数：13
相关论文
共 150 条
[1]   Liver Ischemia/Reperfusion Injury: Processes in Inflammatory Networks-A Review [J].
Abu-Amara, Mahmoud ;
Yang, Shi Yu ;
Tapuria, Niteen ;
Fuller, Barry ;
Davidson, Brian ;
Seifalian, Alexander .
LIVER TRANSPLANTATION, 2010, 16 (09) :1016-1032
[2]   NALP3 forms an IL-lβ-Processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder [J].
Agostini, L ;
Martinon, F ;
Burns, K ;
McDermott, MF ;
Hawkins, PN ;
Tschopp, J .
IMMUNITY, 2004, 20 (03) :319-325
[3]   Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage [J].
Alfonso-Loeches, Silvia ;
Pascual-Lucas, Maya ;
Blanco, Ana M. ;
Sanchez-Vera, Irene ;
Guerri, Consuelo .
JOURNAL OF NEUROSCIENCE, 2010, 30 (24) :8285-8295
[4]   Structural, expression, and evolutionary analysis of mouse CIASI [J].
Anderson, JP ;
Mueller, JL ;
Rosengren, S ;
Boyle, DL ;
Schaner, P ;
Cannon, SB ;
Goodyear, CS ;
Hoffman, HM .
GENE, 2004, 338 (01) :25-34
[5]   Phospholipases C and A2 control lysosome-mediated IL-1β secretion:: Implications for inflammatory processes [J].
Andrei, C ;
Margiocco, P ;
Poggi, A ;
Lotti, LV ;
Torrisi, MR ;
Rubartelli, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (26) :9745-9750
[6]   Interleukin-1β, C-X-C Motif Ligand 10, and Interferon-Gamma Serum Levels in Mixed Cryoglobulinemia With or Without Autoimmune Thyroiditis [J].
Antonelli, Alessandro ;
Ferri, Clodoveo ;
Ferrari, Silvia Martina ;
De Marco, Salvatore ;
Di Domenicantonio, Andrea ;
Centanni, Marco ;
Pupilli, Cinzia ;
Villa, Erica ;
Menichetti, Francesco ;
Fallahi, Poupak .
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2010, 30 (11) :835-842
[7]   Serum Levels of Proinflammatory Cytokines Interleukin-1β, Interleukin-6, and Tumor Necrosis Factor α in Mixed Cryoglobulinemia [J].
Antonelli, Alessandro ;
Ferri, Clodoveo ;
Ferrari, Silvia Martina ;
Ghiri, Emiliano ;
Goglia, Fernando ;
Pampana, Alessandro ;
Bruschi, Fabrizio ;
Fallahi, Poupak .
ARTHRITIS AND RHEUMATISM, 2009, 60 (12) :3841-3847
[8]   Toll-Like Receptor 9 Inhibition Confers Protection from Liver Ischemia-Reperfusion Injury [J].
Bamboat, Zubin M. ;
Balachandran, Vinod P. ;
Ocuin, Lee M. ;
Obaid, Hebroon ;
Plitas, George ;
DeMatteo, Ronald P. .
HEPATOLOGY, 2010, 51 (02) :621-632
[9]   Serum inflammatory cytokines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis [J].
Barak, V. ;
Selmi, C. ;
Schlesinger, M. ;
Blank, M. ;
Agmon-Levin, N. ;
Kalickman, I. ;
Gershwin, M. E. ;
Shoenfeld, Y. .
JOURNAL OF AUTOIMMUNITY, 2009, 33 (3-4) :178-182
[10]   Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome [J].
Bauernfeind, Franz ;
Bartok, Eva ;
Rieger, Anna ;
Franchi, Luigi ;
Nunez, Gabriel ;
Hornung, Veit .
JOURNAL OF IMMUNOLOGY, 2011, 187 (02) :613-617
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