Inflammasomes in liver diseases

被引：461
作者：
Szabo, Gyongyi [1 ]
Csak, Timea [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA
来源：
JOURNAL OF HEPATOLOGY | 2012年 / 57卷 / 03期
关键词：
Inflammasomes; Interleukin-1; beta; Caspase-1; Drug induced liver injury; Ischaemiareperfusion; Endotoxin; Steatohepatitis; Viral hepatitis; Fibrosis; INTERLEUKIN-1 RECEPTOR ANTAGONIST; ACETAMINOPHEN-INDUCED HEPATOTOXICITY; HEPATIC ISCHEMIA/REPERFUSION INJURY; ISCHEMIA-REPERFUSION INJURY; CASPASE RECRUITMENT DOMAIN; III SECRETION APPARATUS; INNATE IMMUNE-RESPONSE; NECROSIS-FACTOR-ALPHA; ANTHRAX LETHAL TOXIN; VIRUS CORE PROTEIN;
D O I：
10.1016/j.jhep.2012.03.035
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Inflammation is a common element in the pathogenesis of most chronic liver diseases that lead to fibrosis and cirrhosis. Inflammation is characterized by activation of innate immune cells and production of pro-inflammatory cytokines IL-1 alpha, IL-1 beta, and TNF alpha. Inflammasomes are intracellular multiprotein complexes expressed in both parenchymal and non-parenchymal cells of the liver that in response to cellular danger signals activate caspase-1, and release IL-1 beta and IL-18. The importance of inflamma-some activation in various forms of liver diseases in relation to liver damage, steatosis, inflammation and fibrosis is discussed in this review. (C) 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：642 / 654
页数：13
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