Development of a Robust Procedure for the Copper-catalyzed Ring-Opening of Epoxides with Grignard Reagents

被引：40
|
作者：
Alam, Mahbub [1 ]
Wise, Christopher [1 ]
Baxter, Carl A. [1 ]
Cleator, Ed [1 ]
Walkinshaw, Andrew [1 ]
机构：
[1] Merck Sharp & Dohme Ltd, Global Proc Chem, Hoddesdon EN11 9BU, England
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2012年 / 16卷 / 03期
关键词：
STEREOCONTROLLED SYNTHESIS; FRAGMENT; ROUTE; PHARMACOPHORE; GLYCIDOL; LACTONE;
D O I：
10.1021/op200329x
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A general procedure for the copper-catalyzed regioselective ring-opening of epoxides with Grignard reagents is described. The procedure developed provides robust reaction conditions which limit the formation of impurities and has been applied successfully using a series of epoxides and Grignard reagents to provide the desired products in >90% yield with excellent regioselectivity and purity.
引用
收藏
页码：435 / 441
页数：7
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