Nanoparticle release from dental composites

被引：60

作者：

Van Landuyt, K. L. ^{[1
,2
]}

Hellack, B. ^{[3
]}

Van Meerbeek, B. ^{[1
,2
]}

Peumans, M. ^{[1
,2
]}

Hoet, P. ^{[4
]}

Wiemann, M. ^{[5
]}

Kuhlbusch, T. A. J. ^{[3
]}

Asbach, C. ^{[3
]}

机构：

[1] Univ Louvain, KU Leuven BIOMAT, Dept Oral Hlth Sci, B-3000 Louvain, Belgium

[2] Katholieke Univ Leuven Hosp, B-3000 Louvain, Belgium

[3] Inst Energy & Environm Technol IUTA eV, D-47229 Duisburg, Germany

[4] Univ Louvain, Res Unit Expt Toxicol, Ctr Environm & Hlth Res, Dept Publ Hlth & Primary Care, B-3001 Louvain, Belgium

[5] IBE R&D gGmbH, Inst Lung Hlth, D-48149 Munster, Germany

来源：

ACTA BIOMATERIALIA | 2014年 / 10卷 / 01期

关键词：

Dental composite; Nanoparticle; Biocompatibility; Filler; Dust; OCCUPATIONAL RESPIRATORY HYPERSENSITIVITY; PARTICLE NUMBER CONCENTRATIONS; SILICA NANOPARTICLES; PARTICULATE MATTER; OXIDATIVE STRESS; SIZE DISTRIBUTIONS; AIR-POLLUTION; EXPOSURE; ULTRAFINE; TOXICITY;

D O I：

10.1016/j.actbio.2013.09.044

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Dental composites typically contain high amounts (up to 60 vol.%) of nanosized filler particles. There is a current concern that dental personnel (and patients) may inhale nanosized dust particles (<100 nm) during abrasive procedures to shape, finish or remove restorations but, so far, whether airborne nanopartides are released has never been investigated. In this study, composite dust was analyzed in real work conditions. Exposure measurements of dust in a dental clinic revealed high peak concentrations of nanoparticles in the breathing zone of both dentist and patient, especially during aesthetic treatments or treatments of worn teeth with composite build-ups. Further laboratory assessment confirmed that all tested composites released very high concentrations of airborne particles in the nanorange (>10(6) cm(-3)). The median diameter of airborne composite dust varied between 38 and 70 nm. Electron microscopic and energy dispersive X-ray analysis confirmed that the airborne particles originated from the composite, and revealed that the dust particles consisted of filler particles or resin or both. Though composite dust exhibited no significant oxidative reactivity, more toxicological research is needed. To conclude, on manipulation with the bur, dental composites release high concentrations of nanoparticles that may enter deeply into the lungs. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：365 / 374

页数：10

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