Neuromyelitis optica in patients with coexisting human immunodeficiency virus infections

被引：15

作者：

Feyissa, Anteneh M. ^{[1
]}

Singh, Parbhdeep ^{[1
]}

Smith, Robert G. ^{[1
]}

机构：

[1] Univ Texas Med Branch, Dept Neurol, Galveston, TX 77555 USA

来源：

MULTIPLE SCLEROSIS JOURNAL | 2013年 / 19卷 / 10期

关键词：

Aquaporin-4; antibody; Devic's disease; HIV; neuromyelitis optica; NMO; plasma exchange;

D O I：

10.1177/1352458513483891

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two patients with known human immunodeficiency virus (HIV) infections and receiving antiretroviral treatment developed neuromyelitis optica (Devic's disease). One patient tested positive for serum aquaporin-4 immunoglobulin G antibodies. Both patients were treated with high dose pulsed intravenous methylprednisolone followed by standard sessions of plasma exchange both at the onset attack and during disease relapses. For maintenance therapy, one patient received rituximab infusions and the second patient received mycophenolate mofetil orally. Despite treatment, both patients are currently wheelchair-bound due to severe paraparesis. Neuromyelitis optica can occur in the course of HIV infection and poses an ongoing therapeutic challenge.

引用

页码：1363 / 1366

页数：4

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