The synthesis and biological characterization of a ceramide library

被引：63
作者：
Chang, YT
Choi, J
Ding, S
Prieschl, EE
Baumruker, T
Lee, JM
Chung, SK
Schultz, PG
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Novartis Res Inst, Dept Immunol, Vienna, Austria
[3] Pohang Univ Sci & Technol, Dept Chem, Div Mol & Life Sci, Pohang 790784, South Korea
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 09期
关键词：
D O I：
10.1021/ja017576o
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile synthesis of a combinatorial ceramide library and their activities in the NF-κB pathway and in apoptosis induction/prevention were demonstrated. A novel NF-κB activating molecule was discovered among ceramide containing β-galactose, and the structural requirements of ceramides for apoptosis induction was elucidated. Copyright © 2002 American Chemical Society.
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收藏
页码：1856 / 1857
页数：2
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