Novel and effective synthesis protocol of AgNPs functionalized using L-cysteine as a potential drug carrier

被引：20

作者：

Wojnicki, Marek ^{[1
]}

Luty-Blocho, Magdalena ^{[1
]}

Kotanska, Magdalena ^{[2
]}

Wytrwal, Magdalena ^{[3
]}

Tokarski, Tomasz ^{[3
]}

Krupa, Anna ^{[4
]}

Kolaczkowski, Marcin ^{[5
]}

Bucki, Adam ^{[5
]}

Kobielusz, Marcin ^{[6
]}

机构：

[1] AGH Univ Sci & Technol, Fac Nonferrous Met, Al A Mickiewicza 30, PL-30059 Krakow, Poland

[2] Jagiellonian Univ, Coll Med, Chair Pharm, Dept Pharmacol Screening, 9 Med St, PL-30688 Krakow, Poland

[3] AGH Univ Sci & Technol, Acad Ctr Mat & Nanotechnol, Al A Mickiewicza 30, PL-30059 Krakow, Poland

[4] Jagiellonian Univ, Coll Med, Dept Pharmaceut Technol & Biopharmaceut, 9 Med St, PL-30688 Krakow, Poland

[5] Jagiellonian Univ, Coll Med, Dept Med Chem, 9 Med St, PL-30688 Krakow, Poland

[6] Jagiellonian Univ, Fac Chem, Ul Ingardena 3, PL-30060 Krakow, Poland

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2018年 / 391卷 / 02期

关键词：

Silver nanoparticles; Functionalization; L-cysteine; Toxicity; Drug carrier; Synthesis; SILVER NANOPARTICLES; TISSUE DISTRIBUTION; GOLD NANOPARTICLES; EMISSION;

D O I：

10.1007/s00210-017-1440-x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, the protocol of a single-step l-cysteine functionalized silver nanoparticle synthesis was described. Particle size distribution was determined. The crystallinity and chemical properties were investigated using XRD, HR-TEM, and XPS methods. Acute toxicity and irritant properties of obtained nanoparticles were studied using mice and rats as an animal model. The results showed that thanks to the applied protocol, it was possible to synthesize silver nanoparticles with narrow particle size distribution. Moreover, the concentration of final product was extremely high in comparison to other known methods. These nanoparticles showed neither irritant properties nor acute toxicity.

引用

页码：123 / 130

页数：8

共 19 条

[1] Silver nanoparticles linked by a Pt-containing organometallic dithiol bridge: study of local structure and interface by XAFS and SR-XPS [J].