Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules

被引：101

作者：

Bugarcic, Zivadin D. ^{[1
]}

Bogojeski, Jovana ^{[1
]}

Petrovic, Biljana ^{[1
]}

Hochreuther, Stephanie ^{[2
]}

van Eldik, Rudi ^{[2
]}

机构：

[1] Univ Kragujevac, Fac Sci, Dept Chem, Kragujevac 34000, Serbia

[2] Univ Erlangen Nurnberg, Dept Chem & Pharm, D-91058 Erlangen, Germany

来源：

DALTON TRANSACTIONS | 2012年 / 41卷 / 40期

关键词：

RAY CRYSTAL-STRUCTURE; ANTICANCER DRUG CARBOPLATIN; ACIDIC AQUEOUS-SOLUTION; BOUND L-METHIONINE; SUBSTITUTION-REACTIONS; BIS(PLATINUM) COMPLEXES; ANTITUMOR-ACTIVITY; PT(II) COMPLEXES; STRUCTURAL-CHARACTERIZATION; GUANOSINE; 5-MONOPHOSPHATE;

D O I：

10.1039/c2dt31045g

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A brief overview of mechanistic studies on the reactions of different Pt(II) complexes with nitrogen- and sulfur-donor biomolecules is presented. The first part describes the results obtained for substitution reactions of mono-functional Pt(II) complexes with different biomolecules, under various experimental conditions (temperature, pH and ionic strength). In addition, an overview of the results obtained for the substitution reactions of bi-functional Pt(II) complexes, analogous to cisplatin, with biomolecules is given. The last part of this report deals with different polynuclear Pt(II) complexes and their substitution behaviour with different biomolecules. The purpose of this perspective is to improve the understanding of the mechanism of action of Pt(II) complexes as potential anti-tumour drugs in the human body.

引用

页码：12329 / 12345

页数：17

共 142 条

[1] Model platinum nucleobase and nucleoside complexes and antitumor activity:: X-ray crystal structure of [PtIV(trans-1 R,2R-diaminocyclohexane) trans-(acetate)2(9-ethylguanine)Cl]NO3 • H2O [J].

Ali, MS ;

Khan, SRA ;

Ojima, H ;

Guzman, IY ;

Whitmire, KH ;

Siddik, ZH ;

Khokhar, AR .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2005, 99 (03) :795-804

[2] Nucleophilicity of thiols towards planar tetracoordinated platinum(II) complexes [J].

Annibale, G ;

Brandolisio, M ;

Bugarcic, Z ;

Cattalini, L .

TRANSITION METAL CHEMISTRY, 1998, 23 (06) :715-719

[3] NEW ROUTES FOR THE SYNTHESIS OF CHLORO(DIETHYLENETRIAMINE)PLATINUM(II)CHLORIDE AND CHLORO(2,2'/6',2''-TERPYRIDINE)PLATINUM(II) CHLORIDE DIHYDRATE [J].

ANNIBALE, G ;

BRANDOLISIO, M ;

PITTERI, B .

POLYHEDRON, 1995, 14 (03) :451-453

[4] Platination of nucleobases to enhance noncovalent recognition in protein-DNA/RNA complexes [J].

Anzellotti, AI ;

Ma, ES ;

Farrell, N .

INORGANIC CHEMISTRY, 2005, 44 (03) :483-485

[5] SYNTHESIS, CHARACTERIZATION, AND INTERACTION WITH DNA OF THE NOVEL METALLOINTERCALATOR CATIONIC COMPLEX (2,2'6',2''-TERPYRIDINE)METHYLPLATINUM(II) [J].

ARENA, G ;

SCOLARO, LM ;

PASTERNACK, RF ;

ROMEO, R .

INORGANIC CHEMISTRY, 1995, 34 (11) :2994-3002

[6]

Arg W. H., 2005, J AM CHEM SOC, V127, P1382

[7] KINETICS OF COMPLEXATION OF AQUATED PT-II(DIEN) WITH INOSINE AND 1-METHYLINOSINE AS A FUNCTION OF PH [J].

ARPALAHTI, J ;

LEHIKOINEN, P .

INORGANIC CHEMISTRY, 1990, 29 (14) :2564-2567

[8] COORDINATION OF AQUATED CIS-PLATINUM(II) DIAMINES TO PURINE NUCLEOSIDES - KINETICS OF COMPLEX-FORMATION [J].

ARPALAHTI, J ;

LIPPERT, B .

INORGANIC CHEMISTRY, 1990, 29 (01) :104-110

[9] THE REACTIONS BETWEEN TETRACHLOROPLATINATE(II) ANION AND BIDENTATE SULPHUR-NITROGEN CHELATING-AGENTS - A DIRECT ROUTE FOR THE SYNTHESIS OF THE NEUTRAL DICHLORO SPECIES [J].

BALDO, A ;

CHESSA, G ;

MARANGONI, G ;

PITTERI, B .

POLYHEDRON, 1985, 4 (08) :1429-1431

[10] INTERMOLECULAR DISPLACEMENT OF S-BOUND L-METHIONINE ON PLATINUM(II) BY GUANOSINE 5'-MONOPHOSPHATE - IMPLICATIONS FOR THE MECHANISM OF ACTION OF ANTICANCER DRUGS [J].

BARNHAM, KJ ;

DJURAN, MI ;

MURDOCH, PD ;

SADLER, PJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1994, (06) :721-722

← 1 2 3 4 5 6 7 8 9 10 →