Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules

被引：98

作者：

Bugarcic, Zivadin D. ^{[1
]}

Bogojeski, Jovana ^{[1
]}

Petrovic, Biljana ^{[1
]}

Hochreuther, Stephanie ^{[2
]}

van Eldik, Rudi ^{[2
]}

机构：

[1] Univ Kragujevac, Fac Sci, Dept Chem, Kragujevac 34000, Serbia

[2] Univ Erlangen Nurnberg, Dept Chem & Pharm, D-91058 Erlangen, Germany

来源：

DALTON TRANSACTIONS | 2012年 / 41卷 / 40期

关键词：

RAY CRYSTAL-STRUCTURE; ANTICANCER DRUG CARBOPLATIN; ACIDIC AQUEOUS-SOLUTION; BOUND L-METHIONINE; SUBSTITUTION-REACTIONS; BIS(PLATINUM) COMPLEXES; ANTITUMOR-ACTIVITY; PT(II) COMPLEXES; STRUCTURAL-CHARACTERIZATION; GUANOSINE; 5-MONOPHOSPHATE;

D O I：

10.1039/c2dt31045g

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A brief overview of mechanistic studies on the reactions of different Pt(II) complexes with nitrogen- and sulfur-donor biomolecules is presented. The first part describes the results obtained for substitution reactions of mono-functional Pt(II) complexes with different biomolecules, under various experimental conditions (temperature, pH and ionic strength). In addition, an overview of the results obtained for the substitution reactions of bi-functional Pt(II) complexes, analogous to cisplatin, with biomolecules is given. The last part of this report deals with different polynuclear Pt(II) complexes and their substitution behaviour with different biomolecules. The purpose of this perspective is to improve the understanding of the mechanism of action of Pt(II) complexes as potential anti-tumour drugs in the human body.

引用

页码：12329 / 12345

页数：17

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