Hydroxypatite-polysaccharide granules for drug delivery

被引:22
作者
Krylova, E
Ivanov, A
Orlovski, V
El-Registan, G
Barinov, S
机构
[1] RAS, High Tech Ceram Res Ctr, Moscow 119361, Russia
[2] Russian Acad Sci, Sci & Technol Ctr Spectrum, Moscow 117907, Russia
[3] RAES, Moscow 117907, Russia
[4] Russian Acad Sci, NS Kurnakov Gen & Inorgan Chem Inst, Moscow 117907, Russia
[5] Russian Acad Sci, Inst Microbiol, Moscow 117811, Russia
关键词
D O I
10.1023/A:1013603106502
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The formation of hydroxyapatite by co-precipitation from sodium alginate and sodium carboxymethylcellulose aqueous solutions with the use of dibasic calcium phosphate dihydrate and calcium hydroxide as starting reagents is studied. A technique to prepare the hydroxyapatite/polysaccharide (micro)granules is developed. An introduction of an antimicrobial Biocide 1 agent in proper amount into the granules is provided, and the behavior of the granules is evaluated. (C) 2002 Kluwer Academic Publishers.
引用
收藏
页码:87 / 90
页数:4
相关论文
共 11 条
[1]  
CERRAI P, 1999, J MATER SCI-MATER M, V10, P238
[2]  
Di Silvio L, 1999, J MATER SCI-MATER M, V10, P653
[3]   BIODEGRADABLE MICROSPHERES - A NEW DELIVERY SYSTEM FOR GROWTH-HORMONE [J].
DISILVIO, L ;
GURAV, N ;
KAYSER, MV ;
BRADEN, M ;
DOWNES, S .
BIOMATERIALS, 1994, 15 (11) :931-936
[4]   THE USE OF GELATIN AS A VEHICLE FOR DRUG AND PEPTIDE DELIVERY [J].
DISILVIO, L ;
COURTENEYHARRIS, RG ;
DOWNES, S .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1994, 5 (11) :819-823
[5]  
GASCONE MG, 1994, J MATER SCI-MATER M, V5, P770
[6]  
GASCONE MG, 1995, BIOMATERIALS, V16, P569
[7]  
GASCONE MG, 1999, J MATER SCI-MATER M, V10, P301
[8]   MODERN STRATEGIES IN THE PREVENTION OF POLYMER-ASSOCIATED INFECTIONS [J].
JANSEN, B ;
PETERS, G .
JOURNAL OF HOSPITAL INFECTION, 1991, 19 (02) :83-88
[9]  
KRYLOVA EA, 1997, P INT WORKSH BIOENC
[10]  
PONCELET D, 1992, APPL MICROBIOL BIOT, V38, P39