The design and synthesis of sulfur containing bisphosphonic acids for the treatment of arthritis

被引：15

作者：

Almstead, NG ^{[1
]}

Dansereau, SM ^{[1
]}

Francis, MD ^{[1
]}

Snider, CM ^{[1
]}

Ebetino, FH ^{[1
]}

机构：

[1] Procter & Gamble Pharmaceut, Hlth Care Res Ctr, Mason, OH 45040 USA

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1999年 / 144卷

关键词：

bisphosphonate; arthritis; antiinflammatory;

D O I：

10.1080/10426509908546247

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The sulfur containing bisphosphonic acids have been examined as a chondroprotective therapy for the treatment of arthritis. Several compounds have demonstrated both in vitro and in vivo activity. The newly synthesized compounds all contain a latent or a free thiol group which may bind to the zinc atom in the active site of the matrix metalloproteases. The in vivo activity of some of these bisphosphonic acids in the rat adjuvant model of arthritis is also discussed.

引用

页码：325 / 328

页数：4

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