Recent insights into Entamoeba development: Identification of transcriptional networks associated with stage conversion

被引：19

作者：

Singh, Upinder ^{[1
,2
]}

Ehrenkaufer, Gretchen M. ^{[2
]}

机构：

[1] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Internal Med, Div Infect Dis, Stanford, CA 94305 USA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2009年 / 39卷 / 01期

关键词：

Microarray; Gene expression; Cyst; Trophozoite; Encystation; CHAIN FATTY-ACIDS; METACYSTIC DEVELOPMENT; GENE-EXPRESSION; OLIGONUCLEOTIDE MICROARRAY; CHITIN SYNTHASE; REGULATED GENES; HISTOLYTICA; ENCYSTATION; INVADENS; EXCYSTATION;

D O I：

10.1016/j.ijpara.2008.09.004

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Entamoeba histolytica is an important human pathogen and a leading parasitic cause of death globally. The parasite life cycle alternates between the trophozoite form, which is motile and causes invasive disease and the cyst stage. which is environmentally resistant and transmits infection. Understanding the triggers that initiate stage conversion is an important yet understudied area of investigation. Recent progress in dissecting the transcriptional networks that regulate E. histolytica development is outlined in this paper. (C) 2008 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：41 / 47

页数：7

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