KIF5B-MET Gene Rearrangement with Robust Antitumor Activity in Response to Crizotinib in Lung Adenocarcinoma

被引:39
作者
Cho, Jang Ho [1 ]
Ku, Bo Mi [2 ]
Sun, Jong-Mu [1 ]
Lee, Se-Hoon [1 ]
Ahn, Jin Seok [1 ]
Park, Keunchil [1 ]
Ahn, Myung-Ju [1 ]
机构
[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Hematol Oncol,Dept Med, 81 Irwon Ro, Seoul 135710, South Korea
[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Samsung Biomed Res Inst, Seoul, South Korea
关键词
MET; ACTIVATION; CANCER;
D O I
10.1016/j.jtho.2017.10.014
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:E29 / E31
页数:3
相关论文
共 7 条
[1]   Responses to Crizotinib Can Occur in High-Level MET-Amplified Non-Small Cell Lung Cancer Independent of MET Exon 14 Alterations [J].
Caparica, Rafael ;
Yen, Cheng Tzu ;
Coudry, Renata ;
Ignatius, Sai-Hong ;
Varella-Garcia, Marileila ;
Camidge, D. Ross ;
de Castro, Gilberto, Jr. .
JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (01) :141-144
[2]   Activation of MET via Diverse Exon 14 Splicing Alterations Occurs in Multiple Tumor Types and Confers Clinical Sensitivity to MET Inhibitors [J].
Frampton, Garrett M. ;
Ali, Siraj M. ;
Rosenzweig, Mark ;
Chmielecki, Juliann ;
Lu, Xinyuan ;
Bauer, Todd M. ;
Akimov, Mikhail ;
Bufill, Jose A. ;
Lee, Carrie ;
Jentz, David ;
Hoover, Rick ;
Ou, Sai-Hong Ignatius ;
Salgia, Ravi ;
Brennan, Tim ;
Chalmers, Zachary R. ;
Jaeger, Savina ;
Huang, Alan ;
Elvin, Julia A. ;
Erlich, Rachel ;
Fichtenholtz, Alex ;
Gowen, Kyle A. ;
Greenbowe, Joel ;
Johnson, Adrienne ;
Khaira, Depinder ;
McMahon, Caitlin ;
Sanford, Eric M. ;
Roels, Steven ;
White, Jared ;
Greshock, Joel ;
Schlegel, Robert ;
Lipson, Doron ;
Yelensky, Roman ;
Morosini, Deborah ;
Ross, Jeffrey S. ;
Collisson, Eric ;
Peters, Malte ;
Stephens, Philip J. ;
Miller, Vincent A. .
CANCER DISCOVERY, 2015, 5 (08) :850-859
[3]   Response to Crizotinib in a Patient With Lung Adenocarcinoma Harboring a MET Splice Site Mutation [J].
Jenkins, Russell W. ;
Oxnard, Geoffrey R. ;
Elkin, Sheryl ;
Sullivan, E. Kelly ;
Carter, Jennifer L. ;
Barbie, David A. .
CLINICAL LUNG CANCER, 2015, 16 (05) :E101-E104
[4]   Activation of MET by Gene Amplification or by Splice Mutations Deleting the Juxtamembrane Domain in Primary Resected Lung Cancers [J].
Onozato, Ryoichi ;
Kosaka, Takayuki ;
Kuwano, Hiroyuki ;
Sekido, Yoshitaka ;
Yatabe, Yasushi ;
Mitsudomi, Tetsuya .
JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (01) :5-11
[5]   MET exon 14 juxtamembrane splicing mutations: clinical and therapeutical perspectives for cancer therapy [J].
Pilotto, Sara ;
Gkountakos, Anastasios ;
Carbognin, Luisa ;
Scarpa, Aldo ;
Tortora, Giampaolo ;
Bria, Emilio .
ANNALS OF TRANSLATIONAL MEDICINE, 2017, 5 (01)
[6]   Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors [J].
Sequist, Lecia V. ;
Waltman, Belinda A. ;
Dias-Santagata, Dora ;
Digumarthy, Subba ;
Turke, Alexa B. ;
Fidias, Panos ;
Bergethon, Kristin ;
Shaw, Alice T. ;
Gettinger, Scott ;
Cosper, Arjola K. ;
Akhavanfard, Sara ;
Heist, Rebecca S. ;
Temel, Jennifer ;
Christensen, James G. ;
Wain, John C. ;
Lynch, Thomas J. ;
Vernovsky, Kathy ;
Mark, Eugene J. ;
Lanuti, Michael ;
Iafrate, A. John ;
Mino-Kenudson, Mari ;
Engelman, Jeffrey A. .
SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (75)
[7]   The landscape of kinase fusions in cancer [J].
Stransky, Nicolas ;
Cerami, Ethan ;
Schalm, Stefanie ;
Kim, Joseph L. ;
Lengauer, Christoph .
NATURE COMMUNICATIONS, 2014, 5