Impact of Prognostic Factors for Postmastectomy Radiation Therapy of Breast Cancer Patients

被引：0

作者：

Simonov, K. A. ^{[1
]}

Startseva, Zh. A. ^{[1
]}

Slonimskaya, E. M. ^{[1
]}

Velikaya, V. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Tomsk Natl Res Med Ctr, Tomsk 634050, Russia

来源：

PHYSICS OF CANCER: INTERDISCIPLINARY PROBLEMS AND CLINICAL APPLICATIONS (PC IPCA) | 2017年 / 1882卷

关键词：

LYMPH-NODES; RADIOTHERAPY; MASTECTOMY;

D O I：

10.1063/1.5001647

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The study included 196 breast cancer patients with stages T1-3N0-3M0. The comprehensive therapy for breast cancer included surgical operation, chemotherapy, and radiotherapy. Multivariate analysis showed that multifocality growth of tumor (p = 0.004), high grade III (p = 0.008), two metastatic lymph nodes (p = 0.02) were associated with an increased risk of regional node failure in the patients with one to three positive lymph nodes. The prognostic models describing the probability of local recurrences of breast cancer were developed for individualization of the radiation therapy tactics. Postmastectomy radiation therapy in the patients with high-risk breast cancer treated with modified radical mastectomy improves locoregional control, breast cancer-specific survival, does not increase late toxicity.

引用

页数：4

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