Macrophages, Chronic Inflammation, and Insulin Resistance

被引：115
|
作者：
Li, He [1 ]
Meng, Ya [1 ]
He, Shuwang [2 ]
Tan, Xiaochuan [1 ]
Zhang, Yujia [1 ]
Zhang, Xiuli [1 ]
Wang, Lulu [3 ,4 ]
Zheng, Wensheng [1 ,4 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing City Key Lab Drug Delivery Technol & Nove, Beijing 100050, Peoples R China
[2] Shandong DYNE Marine Biopharmaceut Co Ltd, Rongcheng 264300, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China
[4] 1 Xian Nong Tan St, Beijing 100050, Peoples R China
来源：
CELLS | 2022年 / 11卷 / 19期
关键词：
obesity; macrophages; chronic inflammation; insulin resistance; molecular mechanism; TUMOR-NECROSIS-FACTOR; ALTERNATIVELY ACTIVATED MACROPHAGES; ADIPOSE-TISSUE INFLAMMATION; DIET-INDUCED OBESITY; N-TERMINAL KINASE; SKELETAL-MUSCLE INFLAMMATION; LOW-GRADE INFLAMMATION; TNF-ALPHA ANTIBODY; PPAR-GAMMA; IMMUNE CELLS;
D O I：
10.3390/cells11193001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The prevalence of obesity has reached alarming levels, which is considered a major risk factor for several metabolic diseases, including type 2 diabetes (T2D), non-alcoholic fatty liver, atherosclerosis, and ischemic cardiovascular disease. Obesity-induced chronic, low-grade inflammation may lead to insulin resistance, and it is well-recognized that macrophages play a major role in such inflammation. In the current review, the molecular mechanisms underlying macrophages, low-grade tissue inflammation, insulin resistance, and T2D are described. Also, the role of macrophages in obesity-induced insulin resistance is presented, and therapeutic drugs and recent advances targeting macrophages for the treatment of T2D are introduced.
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页数：24
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