Macrophages, Chronic Inflammation, and Insulin Resistance

被引：115

作者：

Li, He ^{[1
]}

Meng, Ya ^{[1
]}

He, Shuwang ^{[2
]}

Tan, Xiaochuan ^{[1
]}

Zhang, Yujia ^{[1
]}

Zhang, Xiuli ^{[1
]}

Wang, Lulu ^{[3
,4
]}

Zheng, Wensheng ^{[1
,4
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing City Key Lab Drug Delivery Technol & Nove, Beijing 100050, Peoples R China

[2] Shandong DYNE Marine Biopharmaceut Co Ltd, Rongcheng 264300, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China

[4] 1 Xian Nong Tan St, Beijing 100050, Peoples R China

来源：

CELLS | 2022年 / 11卷 / 19期

关键词：

obesity; macrophages; chronic inflammation; insulin resistance; molecular mechanism; TUMOR-NECROSIS-FACTOR; ALTERNATIVELY ACTIVATED MACROPHAGES; ADIPOSE-TISSUE INFLAMMATION; DIET-INDUCED OBESITY; N-TERMINAL KINASE; SKELETAL-MUSCLE INFLAMMATION; LOW-GRADE INFLAMMATION; TNF-ALPHA ANTIBODY; PPAR-GAMMA; IMMUNE CELLS;

D O I：

10.3390/cells11193001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The prevalence of obesity has reached alarming levels, which is considered a major risk factor for several metabolic diseases, including type 2 diabetes (T2D), non-alcoholic fatty liver, atherosclerosis, and ischemic cardiovascular disease. Obesity-induced chronic, low-grade inflammation may lead to insulin resistance, and it is well-recognized that macrophages play a major role in such inflammation. In the current review, the molecular mechanisms underlying macrophages, low-grade tissue inflammation, insulin resistance, and T2D are described. Also, the role of macrophages in obesity-induced insulin resistance is presented, and therapeutic drugs and recent advances targeting macrophages for the treatment of T2D are introduced.

引用

页数：24

共 50 条

[1] Macrophages, Inflammation, and Insulin Resistance
Olefsky, Jerrold M.
Glass, Christopher K.
ANNUAL REVIEW OF PHYSIOLOGY, 2010, 72 : 219 - 246
[2] Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Zatterale, Federica
Longo, Michele
Naderi, Jamal
Raciti, Gregory Alexander
Desiderio, Antonella
Miele, Claudia
Beguinot, Francesco
FRONTIERS IN PHYSIOLOGY, 2020, 10
[3] Insulin resistance and chronic inflammation
Matulewicz, Natalia
Karczewska-Kupczewska, Monika
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2016, 70 : 1245 - 1257
[4] Obesity, Inflammation, and Insulin Resistance - A Mini-Review
Zeyda, Maximilian
Stulnig, Thomas M.
GERONTOLOGY, 2009, 55 (04) : 379 - 386
[5] Metabolic Inflammation and Insulin Resistance in Obesity
Wu, Huaizhu
Ballantyne, Christie M.
CIRCULATION RESEARCH, 2020, 126 (11) : 1549 - 1564
[6] Obesity and Insulin Resistance: Associations with Chronic Inflammation, Genetic and Epigenetic Factors
Gasmi, Amin
Noor, Sadaf
Menzel, Alain
Dosa, Alexandru
Pivina, Lyudmila
Bjorklund, Geir
CURRENT MEDICINAL CHEMISTRY, 2021, 28 (04) : 800 - 826
[7] Research Progress Into Adipose Tissue Macrophages and Insulin Resistance
Fu, Mengfei
Yang, Liu
Wang, Hanyu
Chen, Yang
Chen, Xiao
Hu, Qinyu
Sun, Hui
PHYSIOLOGICAL RESEARCH, 2023, 72 (03) : 287 - 299
[8] Inflammation and insulin resistance: chronic renal disease features
Guebre-Egziabher, Fitsum
Juillard, Laurent
Kalbacher, Emilie
Bachetta, Justine
Fouque, Denis
NEPHROLOGIE & THERAPEUTIQUE, 2010, 6 : S7 - S12
[9] Role of immune cells in obesity induced low grade inflammation and insulin resistance
Asghar, Ambreen
Sheikh, Nadeem
CELLULAR IMMUNOLOGY, 2017, 315 : 18 - 26
[10] MicroRNAs link chronic inflammation in childhood to growth impairment and insulin-resistance
Cirillo, Francesca
Lazzeroni, Pietro
Catellani, Cecilia
Sartori, Chiara
Amarri, Sergio
Street, Maria Elisabeth
CYTOKINE & GROWTH FACTOR REVIEWS, 2018, 39 : 1 - 18

← 1 2 3 4 5 →